Frequent Loss and Alteration of the MOXD2 Gene in Catarrhines and Whales: A Possible Connection with the Evolution of Olfaction

The MOXD2 gene encodes a membrane-bound monooxygenase similar to dopamine-β-hydroxylase, and has been proposed to be associated with olfaction. In this study, we analyzed MOXD2 genes from 64 mammalian species, and identified loss-of-function mutations in apes (humans, Sumatran and Bornean orangutans...

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Bibliographic Details
Published in:PLoS ONE
Main Authors: Kim, Dong Seon, Wang, Yao, Oh, Hye Ji, Lee, Kangseok, Hahn, Yoonsoo
Format: Text
Language:English
Published: Public Library of Science 2014
Subjects:
Research Article
Gibbon
baleen whales
toothed whales
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125168
http://www.ncbi.nlm.nih.gov/pubmed/25102179
https://doi.org/10.1371/journal.pone.0104085
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Summary:The MOXD2 gene encodes a membrane-bound monooxygenase similar to dopamine-β-hydroxylase, and has been proposed to be associated with olfaction. In this study, we analyzed MOXD2 genes from 64 mammalian species, and identified loss-of-function mutations in apes (humans, Sumatran and Bornean orangutans, and five gibbon species from the four major gibbon genera), toothed whales (killer whales, bottlenose dolphins, finless porpoises, baijis, and sperm whales), and baleen whales (minke whales and fin whales). We also identified a shared 13-nt deletion in the last exon of Old World cercopithecine monkeys that results in conversion of a membrane-bound protein to a soluble form. We hypothesize that the frequent inactivation and alteration of MOXD2 genes in catarrhines and whales may be associated with the evolution of olfaction in these clades.

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