Oxygen-Linked S-Nitrosation in Fish Myoglobins: A Cysteine-Specific Tertiary Allosteric Effect

• Published in: PLoS ONE
• Main Authors: Helbo, Signe, Gow, Andrew J., Jamil, Amna, Howes, Barry D., Smulevich, Giulietta, Fago, Angela
• Format: Text
• Language: English
• Published: Public Library of Science 2014
• Subjects: Research Article; Kon; Atlantic salmon
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039430; http://www.ncbi.nlm.nih.gov/pubmed/24879536; https://doi.org/10.1371/journal.pone.0097012

The discovery that cysteine (Cys) S-nitrosation of trout myoglobin (Mb) increases heme O2 affinity has revealed a novel allosteric effect that may promote hypoxia-induced nitric oxide (NO) delivery in the trout heart and improve myocardial efficiency. To better understand this allosteric effect, we...