Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu
The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or sialyl(α2-6) linkage specificity of oligosaccharide moieties f...
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ftpubmed:oai:pubmedcentral.nih.gov:3975476 2023-05-15T15:34:24+02:00 Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu Yoo, Eunsun 2014-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975476 http://www.ncbi.nlm.nih.gov/pubmed/24753813 https://doi.org/10.4062/biomolther.2014.005 en eng The Korean Society of Applied Pharmacology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975476 http://www.ncbi.nlm.nih.gov/pubmed/24753813 http://dx.doi.org/10.4062/biomolther.2014.005 Copyright © 2014 The Korean Society of Applied Pharmacology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Review Text 2014 ftpubmed https://doi.org/10.4062/biomolther.2014.005 2014-04-27T00:32:35Z The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or sialyl(α2-6) linkage specificity of oligosaccharide moieties for avian or human virus, respectively. In the case of H5N1 and newly mutated flu viruses, classification based on the linkage type does not correlate with human infection and human-to-human transmission of these viruses. It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(α2-6)galactose containing oligosaccharides. On the other hand, the avian flu virus requires folded conformation with sialyl(α2-3) or short length sialyl(α2-6) containing trisaccharides. This suggests a potential future direction for the development of new species-specific antiviral drugs to prevent and treat pandemic flu. Text Avian flu PubMed Central (PMC) Biomolecules & Therapeutics 22 2 93 99 |
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Review Yoo, Eunsun Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
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The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or sialyl(α2-6) linkage specificity of oligosaccharide moieties for avian or human virus, respectively. In the case of H5N1 and newly mutated flu viruses, classification based on the linkage type does not correlate with human infection and human-to-human transmission of these viruses. It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(α2-6)galactose containing oligosaccharides. On the other hand, the avian flu virus requires folded conformation with sialyl(α2-3) or short length sialyl(α2-6) containing trisaccharides. This suggests a potential future direction for the development of new species-specific antiviral drugs to prevent and treat pandemic flu. |
format |
Text |
author |
Yoo, Eunsun |
author_facet |
Yoo, Eunsun |
author_sort |
Yoo, Eunsun |
title |
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
title_short |
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
title_full |
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
title_fullStr |
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
title_full_unstemmed |
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu |
title_sort |
conformation and linkage studies of specific oligosaccharides related to h1n1, h5n1, and human flu for developing the second tamiflu |
publisher |
The Korean Society of Applied Pharmacology |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975476 http://www.ncbi.nlm.nih.gov/pubmed/24753813 https://doi.org/10.4062/biomolther.2014.005 |
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Avian flu |
genre_facet |
Avian flu |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975476 http://www.ncbi.nlm.nih.gov/pubmed/24753813 http://dx.doi.org/10.4062/biomolther.2014.005 |
op_rights |
Copyright © 2014 The Korean Society of Applied Pharmacology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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CC-BY-NC |
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https://doi.org/10.4062/biomolther.2014.005 |
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Biomolecules & Therapeutics |
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22 |
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2 |
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93 |
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99 |
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1766364812100501504 |