Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106
Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as...
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ftpubmed:oai:pubmedcentral.nih.gov:3967205 2023-05-15T16:28:18+02:00 Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. 2014-03-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205 http://www.ncbi.nlm.nih.gov/pubmed/24663111 https://doi.org/10.3390/md12031208 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205 http://www.ncbi.nlm.nih.gov/pubmed/24663111 http://dx.doi.org/10.3390/md12031208 © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2014 ftpubmed https://doi.org/10.3390/md12031208 2014-03-30T01:54:43Z Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively. Text Greenland PubMed Central (PMC) Greenland Marine Drugs 12 3 1208 1219 |
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Article Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
topic_facet |
Article |
description |
Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC50 values of 24 μM and 4 μM, respectively. |
format |
Text |
author |
Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. |
author_facet |
Wu, Bin Oesker, Vanessa Wiese, Jutta Schmaljohann, Rolf Imhoff, Johannes F. |
author_sort |
Wu, Bin |
title |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_short |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_full |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_fullStr |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_full_unstemmed |
Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 |
title_sort |
two new antibiotic pyridones produced by a marine fungus, trichoderma sp. strain mf106 |
publisher |
MDPI |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205 http://www.ncbi.nlm.nih.gov/pubmed/24663111 https://doi.org/10.3390/md12031208 |
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Greenland |
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Greenland |
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Greenland |
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Greenland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967205 http://www.ncbi.nlm.nih.gov/pubmed/24663111 http://dx.doi.org/10.3390/md12031208 |
op_rights |
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md12031208 |
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Marine Drugs |
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1208 |
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