Ancient human genome sequence of an extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to...
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ftpubmed:oai:pubmedcentral.nih.gov:3951495 2023-05-15T16:06:58+02:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders 2010-02-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951495 http://www.ncbi.nlm.nih.gov/pubmed/20148029 https://doi.org/10.1038/nature08835 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951495 http://www.ncbi.nlm.nih.gov/pubmed/20148029 http://dx.doi.org/10.1038/nature08835 ©2010 Macmillan Publishers Limited. All rights reserved Article Text 2010 ftpubmed https://doi.org/10.1038/nature08835 2014-03-16T01:49:39Z We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Text eskimo* Greenland inuit permafrost Siberia PubMed Central (PMC) Greenland Nature 463 7282 757 762 |
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Article Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Ancient human genome sequence of an extinct Palaeo-Eskimo |
topic_facet |
Article |
description |
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Text |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M. Thomas P. Wang, Yong Raghavan, Maanasa Campos, Paula F. Kamp, Hanne Munkholm Wilson, Andrew S. Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D. Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L. Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A. Osipova, Ludmila P. Higham, Thomas F. G. Ramsey, Christopher Bronk Hansen, Thomas v. O. Nielsen, Finn C. Crawford, Michael H. Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders |
author_sort |
Rasmussen, Morten |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publishDate |
2010 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951495 http://www.ncbi.nlm.nih.gov/pubmed/20148029 https://doi.org/10.1038/nature08835 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit permafrost Siberia |
genre_facet |
eskimo* Greenland inuit permafrost Siberia |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951495 http://www.ncbi.nlm.nih.gov/pubmed/20148029 http://dx.doi.org/10.1038/nature08835 |
op_rights |
©2010 Macmillan Publishers Limited. All rights reserved |
op_doi |
https://doi.org/10.1038/nature08835 |
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Nature |
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463 |
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7282 |
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757 |
op_container_end_page |
762 |
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1766402976565428224 |