Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century
Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakut...
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ftpubmed:oai:pubmedcentral.nih.gov:3935942 2023-05-15T18:44:33+02:00 Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Géraut, Annie Duchesne, Sylvie Gérard, Patrice Alexeev, Anatoly N. Crubézy, Eric Ludes, Bertrand 2014-02-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935942 http://www.ncbi.nlm.nih.gov/pubmed/24587092 https://doi.org/10.1371/journal.pone.0089877 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935942 http://www.ncbi.nlm.nih.gov/pubmed/24587092 http://dx.doi.org/10.1371/journal.pone.0089877 This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2014 ftpubmed https://doi.org/10.1371/journal.pone.0089877 2014-03-09T01:42:41Z Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16th–19th century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17th century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19th century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. Text Yakut Yakutia Siberia PubMed Central (PMC) PLoS ONE 9 2 e89877 |
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Research Article Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Géraut, Annie Duchesne, Sylvie Gérard, Patrice Alexeev, Anatoly N. Crubézy, Eric Ludes, Bertrand Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
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Research Article |
description |
Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16th–19th century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17th century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19th century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. |
format |
Text |
author |
Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Géraut, Annie Duchesne, Sylvie Gérard, Patrice Alexeev, Anatoly N. Crubézy, Eric Ludes, Bertrand |
author_facet |
Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Géraut, Annie Duchesne, Sylvie Gérard, Patrice Alexeev, Anatoly N. Crubézy, Eric Ludes, Bertrand |
author_sort |
Dabernat, Henri |
title |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
title_short |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
title_full |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
title_fullStr |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
title_full_unstemmed |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16th-19th Century |
title_sort |
tuberculosis epidemiology and selection in an autochthonous siberian population from the 16th-19th century |
publisher |
Public Library of Science |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935942 http://www.ncbi.nlm.nih.gov/pubmed/24587092 https://doi.org/10.1371/journal.pone.0089877 |
genre |
Yakut Yakutia Siberia |
genre_facet |
Yakut Yakutia Siberia |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935942 http://www.ncbi.nlm.nih.gov/pubmed/24587092 http://dx.doi.org/10.1371/journal.pone.0089877 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0089877 |
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PLoS ONE |
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9 |
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2 |
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e89877 |
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