Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12
Several taxa of animals fast completely from food and water during energy-intensive periods such as lactation, breeding, and development. In elephant seals, these behaviors are sustained by high adiposity, high rates of fat mobilization, and reduced oxidation of carbohydrates and proteins. Adiposity...
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ftpubmed:oai:pubmedcentral.nih.gov:3884100 2023-05-15T16:05:41+02:00 Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 Crocker, Daniel E. Champagne, Cory D. Fowler, Melinda A. Houser, Dorian S. 2014-01-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884100 http://www.ncbi.nlm.nih.gov/pubmed/24425723 https://doi.org/10.3945/an.113.004663 en eng American Society for Nutrition http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/24425723 http://dx.doi.org/10.3945/an.113.004663 © 2014 American Society for Nutrition Reviews from ASN EB 2013 Symposia Text 2014 ftpubmed https://doi.org/10.3945/an.113.004663 2015-01-04T00:59:31Z Several taxa of animals fast completely from food and water during energy-intensive periods such as lactation, breeding, and development. In elephant seals, these behaviors are sustained by high adiposity, high rates of fat mobilization, and reduced oxidation of carbohydrates and proteins. Adiposity and the regulation of lipolysis directly affect lactation energetics, milk composition, and mating success. Long-term fasting induces changes in regulation of lipolysis and lipid metabolism that influence fatty acid (FA) availability and the onset of insulin resistance. Hypoinsulinemia and elevated circulating FAs are also associated with several unique features of carbohydrate metabolism, including elevated plasma glucose, gluconeogenesis, and Cori cycle activity as well as high rates of pyruvate and tricarboxylic acid cycling. Glucose-lactate pools and triacylglycerol-FA cycles may be linked via glyceroneogenesis and this may be an important pathway influencing both fat and carbohydrate metabolism. Together, these features allow a sustained, high intensity, fat-based metabolism without substantial accumulation of ketoacids. Text Elephant Seals PubMed Central (PMC) Advances in Nutrition 5 1 57 64 |
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Reviews from ASN EB 2013 Symposia |
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Reviews from ASN EB 2013 Symposia Crocker, Daniel E. Champagne, Cory D. Fowler, Melinda A. Houser, Dorian S. Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
topic_facet |
Reviews from ASN EB 2013 Symposia |
description |
Several taxa of animals fast completely from food and water during energy-intensive periods such as lactation, breeding, and development. In elephant seals, these behaviors are sustained by high adiposity, high rates of fat mobilization, and reduced oxidation of carbohydrates and proteins. Adiposity and the regulation of lipolysis directly affect lactation energetics, milk composition, and mating success. Long-term fasting induces changes in regulation of lipolysis and lipid metabolism that influence fatty acid (FA) availability and the onset of insulin resistance. Hypoinsulinemia and elevated circulating FAs are also associated with several unique features of carbohydrate metabolism, including elevated plasma glucose, gluconeogenesis, and Cori cycle activity as well as high rates of pyruvate and tricarboxylic acid cycling. Glucose-lactate pools and triacylglycerol-FA cycles may be linked via glyceroneogenesis and this may be an important pathway influencing both fat and carbohydrate metabolism. Together, these features allow a sustained, high intensity, fat-based metabolism without substantial accumulation of ketoacids. |
format |
Text |
author |
Crocker, Daniel E. Champagne, Cory D. Fowler, Melinda A. Houser, Dorian S. |
author_facet |
Crocker, Daniel E. Champagne, Cory D. Fowler, Melinda A. Houser, Dorian S. |
author_sort |
Crocker, Daniel E. |
title |
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
title_short |
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
title_full |
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
title_fullStr |
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
title_full_unstemmed |
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals12 |
title_sort |
adiposity and fat metabolism in lactating and fasting northern elephant seals12 |
publisher |
American Society for Nutrition |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884100 http://www.ncbi.nlm.nih.gov/pubmed/24425723 https://doi.org/10.3945/an.113.004663 |
genre |
Elephant Seals |
genre_facet |
Elephant Seals |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/24425723 http://dx.doi.org/10.3945/an.113.004663 |
op_rights |
© 2014 American Society for Nutrition |
op_doi |
https://doi.org/10.3945/an.113.004663 |
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Advances in Nutrition |
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5 |
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1 |
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57 |
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64 |
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1766401594827472896 |