Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome

It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the...

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Published in:Veterinary Research
Main Authors: Fagerland, Hilde AS, Austbø, Lars, Fritsvold, Camilla, Alarcon, Marta, Rimstad, Espen, Falk, Knut, Taksdal, Torunn, Koppang, Erling O
Format: Text
Language:English
Published: BioMed Central 2013
Subjects:
Short Report
Atlantic salmon
Salmo salar
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866610
http://www.ncbi.nlm.nih.gov/pubmed/24219276
https://doi.org/10.1186/1297-9716-44-107
id ftpubmed:oai:pubmedcentral.nih.gov:3866610
record_format openpolar
spelling ftpubmed:oai:pubmedcentral.nih.gov:3866610 2023-05-15T15:30:20+02:00 Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome Fagerland, Hilde AS Austbø, Lars Fritsvold, Camilla Alarcon, Marta Rimstad, Espen Falk, Knut Taksdal, Torunn Koppang, Erling O 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866610 http://www.ncbi.nlm.nih.gov/pubmed/24219276 https://doi.org/10.1186/1297-9716-44-107 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866610 http://www.ncbi.nlm.nih.gov/pubmed/24219276 http://dx.doi.org/10.1186/1297-9716-44-107 Copyright © 2013 Fagerland et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Short Report Text 2013 ftpubmed https://doi.org/10.1186/1297-9716-44-107 2013-12-22T01:52:57Z It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the heart. By the use of histology, laser capture microdissection and transcription analysis of tyrosinase genes, we here show that this melanisation is linked to de novo melanogenesis by melanomacrophages, suggesting an active part in the inflammatory reaction. No general systemic activation of the extracutaneous pigmentary system in response to viral infections with affinity to the heart was observed. Text Atlantic salmon Salmo salar PubMed Central (PMC) Veterinary Research 44 1 107
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Short Report
spellingShingle Short Report
Fagerland, Hilde AS
Austbø, Lars
Fritsvold, Camilla
Alarcon, Marta
Rimstad, Espen
Falk, Knut
Taksdal, Torunn
Koppang, Erling O
Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
topic_facet Short Report
description It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the heart. By the use of histology, laser capture microdissection and transcription analysis of tyrosinase genes, we here show that this melanisation is linked to de novo melanogenesis by melanomacrophages, suggesting an active part in the inflammatory reaction. No general systemic activation of the extracutaneous pigmentary system in response to viral infections with affinity to the heart was observed.
format Text
author Fagerland, Hilde AS
Austbø, Lars
Fritsvold, Camilla
Alarcon, Marta
Rimstad, Espen
Falk, Knut
Taksdal, Torunn
Koppang, Erling O
author_facet Fagerland, Hilde AS
Austbø, Lars
Fritsvold, Camilla
Alarcon, Marta
Rimstad, Espen
Falk, Knut
Taksdal, Torunn
Koppang, Erling O
author_sort Fagerland, Hilde AS
title Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
title_short Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
title_full Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
title_fullStr Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
title_full_unstemmed Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
title_sort pathological pigmentation in cardiac tissues of atlantic salmon (salmo salar l.) with cardiomyopathy syndrome
publisher BioMed Central
publishDate 2013
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866610
http://www.ncbi.nlm.nih.gov/pubmed/24219276
https://doi.org/10.1186/1297-9716-44-107
genre Atlantic salmon
Salmo salar
genre_facet Atlantic salmon
Salmo salar
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866610
http://www.ncbi.nlm.nih.gov/pubmed/24219276
http://dx.doi.org/10.1186/1297-9716-44-107
op_rights Copyright © 2013 Fagerland et al.; licensee BioMed Central Ltd.
http://creativecommons.org/licenses/by/2.0
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
op_rightsnorm CC-BY
op_doi https://doi.org/10.1186/1297-9716-44-107
container_title Veterinary Research
container_volume 44
container_issue 1
container_start_page 107
_version_ 1766360780231409664

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