Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12
Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility ge...
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ftpubmed:oai:pubmedcentral.nih.gov:384939 2023-05-15T16:49:57+02:00 Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 Gretarsdottir, Solveig Sveinbjörnsdottir, Sigurlaug Jonsson, Hjörtur H. Jakobsson, Finnbogi Einarsdottir, Elisabet Agnarsson, Uggi Shkolny, Dana Einarsson, Gisli Gudjonsdottir, Herdis M. Valdimarsson, Einar M. Einarsson, Olafur B. Thorgeirsson, Gudmundur Hadzic, Radinka Jonsdottir, Sif Reynisdottir, Sigridur Th. Bjarnadottir, Sigrun M. Gudmundsdottir, Thorunn Gudlaugsdottir, Gudrun J. Gill, Ramanjit Lindpaintner, Klaus Sainz, Jesus Hannesson, Helgi H. Sigurdsson, Gunnar Th. Frigge, Michael L. Kong, Augustine Gudnason, Vilmundur Stefansson, Kari Gulcher, Jeffrey R. 2002-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384939 http://www.ncbi.nlm.nih.gov/pubmed/11833004 en eng The American Society of Human Genetics http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384939 http://www.ncbi.nlm.nih.gov/pubmed/11833004 © 2002 by The American Society of Human Genetics. All rights reserved. Articles Text 2002 ftpubmed 2013-08-29T22:28:11Z Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9×10-6). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as “STRK1,” does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke. Text Iceland PubMed Central (PMC) |
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Articles Gretarsdottir, Solveig Sveinbjörnsdottir, Sigurlaug Jonsson, Hjörtur H. Jakobsson, Finnbogi Einarsdottir, Elisabet Agnarsson, Uggi Shkolny, Dana Einarsson, Gisli Gudjonsdottir, Herdis M. Valdimarsson, Einar M. Einarsson, Olafur B. Thorgeirsson, Gudmundur Hadzic, Radinka Jonsdottir, Sif Reynisdottir, Sigridur Th. Bjarnadottir, Sigrun M. Gudmundsdottir, Thorunn Gudlaugsdottir, Gudrun J. Gill, Ramanjit Lindpaintner, Klaus Sainz, Jesus Hannesson, Helgi H. Sigurdsson, Gunnar Th. Frigge, Michael L. Kong, Augustine Gudnason, Vilmundur Stefansson, Kari Gulcher, Jeffrey R. Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
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Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9×10-6). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as “STRK1,” does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke. |
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Text |
author |
Gretarsdottir, Solveig Sveinbjörnsdottir, Sigurlaug Jonsson, Hjörtur H. Jakobsson, Finnbogi Einarsdottir, Elisabet Agnarsson, Uggi Shkolny, Dana Einarsson, Gisli Gudjonsdottir, Herdis M. Valdimarsson, Einar M. Einarsson, Olafur B. Thorgeirsson, Gudmundur Hadzic, Radinka Jonsdottir, Sif Reynisdottir, Sigridur Th. Bjarnadottir, Sigrun M. Gudmundsdottir, Thorunn Gudlaugsdottir, Gudrun J. Gill, Ramanjit Lindpaintner, Klaus Sainz, Jesus Hannesson, Helgi H. Sigurdsson, Gunnar Th. Frigge, Michael L. Kong, Augustine Gudnason, Vilmundur Stefansson, Kari Gulcher, Jeffrey R. |
author_facet |
Gretarsdottir, Solveig Sveinbjörnsdottir, Sigurlaug Jonsson, Hjörtur H. Jakobsson, Finnbogi Einarsdottir, Elisabet Agnarsson, Uggi Shkolny, Dana Einarsson, Gisli Gudjonsdottir, Herdis M. Valdimarsson, Einar M. Einarsson, Olafur B. Thorgeirsson, Gudmundur Hadzic, Radinka Jonsdottir, Sif Reynisdottir, Sigridur Th. Bjarnadottir, Sigrun M. Gudmundsdottir, Thorunn Gudlaugsdottir, Gudrun J. Gill, Ramanjit Lindpaintner, Klaus Sainz, Jesus Hannesson, Helgi H. Sigurdsson, Gunnar Th. Frigge, Michael L. Kong, Augustine Gudnason, Vilmundur Stefansson, Kari Gulcher, Jeffrey R. |
author_sort |
Gretarsdottir, Solveig |
title |
Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
title_short |
Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
title_full |
Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
title_fullStr |
Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
title_full_unstemmed |
Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12 |
title_sort |
localization of a susceptibility gene for common forms of stroke to 5q12 |
publisher |
The American Society of Human Genetics |
publishDate |
2002 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384939 http://www.ncbi.nlm.nih.gov/pubmed/11833004 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384939 http://www.ncbi.nlm.nih.gov/pubmed/11833004 |
op_rights |
© 2002 by The American Society of Human Genetics. All rights reserved. |
_version_ |
1766040128470384640 |