Abolition of Peroxiredoxin-5 Mitochondrial Targeting during Canid Evolution

• Published in: PLoS ONE
• Main Authors: Van der Eecken, Valérie, Clippe, André, Dekoninck, Sophie, Goemaere, Julie, Walbrecq, Geoffroy, Van Veldhoven, Paul P., Knoops, Bernard
• Format: Text
• Language: English
• Published: Public Library of Science 2013
• Subjects: Research Article; Darby; Elephant Seal
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759418; http://www.ncbi.nlm.nih.gov/pubmed/24023783; https://doi.org/10.1371/journal.pone.0072844

In human, the subcellular targeting of peroxiredoxin-5 (PRDX5), a thioredoxin peroxidase, is dependent on the use of multiple alternative transcription start sites and two alternative in-frame translation initiation sites, which determine whether or not the region encoding a mitochondrial targeting...