Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption, we performed a population-based genome-wide association study of ‘age at first tooth’ and ‘number of teeth’...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749866 http://www.ncbi.nlm.nih.gov/pubmed/23704328 https://doi.org/10.1093/hmg/ddt231 |
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ftpubmed:oai:pubmedcentral.nih.gov:3749866 2023-05-15T17:42:41+02:00 Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances Fatemifar, Ghazaleh Hoggart, Clive J. Paternoster, Lavinia Kemp, John P. Prokopenko, Inga Horikoshi, Momoko Wright, Victoria J. Tobias, Jon H. Richmond, Stephen Zhurov, Alexei I. Toma, Arshed M. Pouta, Anneli Taanila, Anja Sipila, Kirsi Lähdesmäki, Raija Pillas, Demetris Geller, Frank Feenstra, Bjarke Melbye, Mads Nohr, Ellen A. Ring, Susan M. St Pourcain, Beate Timpson, Nicholas J. Davey Smith, George Jarvelin, Marjo-Riitta Evans, David M. 2013-09-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749866 http://www.ncbi.nlm.nih.gov/pubmed/23704328 https://doi.org/10.1093/hmg/ddt231 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749866 http://www.ncbi.nlm.nih.gov/pubmed/23704328 http://dx.doi.org/10.1093/hmg/ddt231 © The Author 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Association Studies Article Text 2013 ftpubmed https://doi.org/10.1093/hmg/ddt231 2013-09-05T04:09:19Z Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption, we performed a population-based genome-wide association study of ‘age at first tooth’ and ‘number of teeth’ using 5998 and 6609 individuals, respectively, from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2 446 724 SNPs imputed in both studies. Analyses were controlled for the effect of gestational age, sex and age of measurement. Results from the two studies were combined using fixed effects inverse variance meta-analysis. We identified a total of 15 independent loci, with 10 loci reaching genome-wide significance (P < 5 × 10−8) for ‘age at first tooth’ and 11 loci for ‘number of teeth’. Together, these associations explain 6.06% of the variation in ‘age of first tooth’ and 4.76% of the variation in ‘number of teeth’. The identified loci included eight previously unidentified loci, some containing genes known to play a role in tooth and other developmental pathways, including an SNP in the protein-coding region of BMP4 (rs17563, P = 9.080 × 10−17). Three of these loci, containing the genes HMGA2, AJUBA and ADK, also showed evidence of association with craniofacial distances, particularly those indexing facial width. Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development. Text Northern Finland PubMed Central (PMC) Human Molecular Genetics 22 18 3807 3817 |
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Association Studies Article |
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Association Studies Article Fatemifar, Ghazaleh Hoggart, Clive J. Paternoster, Lavinia Kemp, John P. Prokopenko, Inga Horikoshi, Momoko Wright, Victoria J. Tobias, Jon H. Richmond, Stephen Zhurov, Alexei I. Toma, Arshed M. Pouta, Anneli Taanila, Anja Sipila, Kirsi Lähdesmäki, Raija Pillas, Demetris Geller, Frank Feenstra, Bjarke Melbye, Mads Nohr, Ellen A. Ring, Susan M. St Pourcain, Beate Timpson, Nicholas J. Davey Smith, George Jarvelin, Marjo-Riitta Evans, David M. Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
topic_facet |
Association Studies Article |
description |
Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption, we performed a population-based genome-wide association study of ‘age at first tooth’ and ‘number of teeth’ using 5998 and 6609 individuals, respectively, from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2 446 724 SNPs imputed in both studies. Analyses were controlled for the effect of gestational age, sex and age of measurement. Results from the two studies were combined using fixed effects inverse variance meta-analysis. We identified a total of 15 independent loci, with 10 loci reaching genome-wide significance (P < 5 × 10−8) for ‘age at first tooth’ and 11 loci for ‘number of teeth’. Together, these associations explain 6.06% of the variation in ‘age of first tooth’ and 4.76% of the variation in ‘number of teeth’. The identified loci included eight previously unidentified loci, some containing genes known to play a role in tooth and other developmental pathways, including an SNP in the protein-coding region of BMP4 (rs17563, P = 9.080 × 10−17). Three of these loci, containing the genes HMGA2, AJUBA and ADK, also showed evidence of association with craniofacial distances, particularly those indexing facial width. Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development. |
format |
Text |
author |
Fatemifar, Ghazaleh Hoggart, Clive J. Paternoster, Lavinia Kemp, John P. Prokopenko, Inga Horikoshi, Momoko Wright, Victoria J. Tobias, Jon H. Richmond, Stephen Zhurov, Alexei I. Toma, Arshed M. Pouta, Anneli Taanila, Anja Sipila, Kirsi Lähdesmäki, Raija Pillas, Demetris Geller, Frank Feenstra, Bjarke Melbye, Mads Nohr, Ellen A. Ring, Susan M. St Pourcain, Beate Timpson, Nicholas J. Davey Smith, George Jarvelin, Marjo-Riitta Evans, David M. |
author_facet |
Fatemifar, Ghazaleh Hoggart, Clive J. Paternoster, Lavinia Kemp, John P. Prokopenko, Inga Horikoshi, Momoko Wright, Victoria J. Tobias, Jon H. Richmond, Stephen Zhurov, Alexei I. Toma, Arshed M. Pouta, Anneli Taanila, Anja Sipila, Kirsi Lähdesmäki, Raija Pillas, Demetris Geller, Frank Feenstra, Bjarke Melbye, Mads Nohr, Ellen A. Ring, Susan M. St Pourcain, Beate Timpson, Nicholas J. Davey Smith, George Jarvelin, Marjo-Riitta Evans, David M. |
author_sort |
Fatemifar, Ghazaleh |
title |
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
title_short |
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
title_full |
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
title_fullStr |
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
title_full_unstemmed |
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
title_sort |
genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances |
publisher |
Oxford University Press |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749866 http://www.ncbi.nlm.nih.gov/pubmed/23704328 https://doi.org/10.1093/hmg/ddt231 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749866 http://www.ncbi.nlm.nih.gov/pubmed/23704328 http://dx.doi.org/10.1093/hmg/ddt231 |
op_rights |
© The Author 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/hmg/ddt231 |
container_title |
Human Molecular Genetics |
container_volume |
22 |
container_issue |
18 |
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3807 |
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3817 |
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1766144594967265280 |