Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1

A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR tech...

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Published in:Marine Drugs
Main Authors: Wu, Guangwei, Lin, Aiqun, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai
Format: Text
Language:English
Published: MDPI 2013
Subjects:
Article
Antarctic
Antarc*
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411
http://www.ncbi.nlm.nih.gov/pubmed/23612371
https://doi.org/10.3390/md11041399
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spelling ftpubmed:oai:pubmedcentral.nih.gov:3705411 2023-05-15T13:56:37+02:00 Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1 Wu, Guangwei Lin, Aiqun Gu, Qianqun Zhu, Tianjiao Li, Dehai 2013-04-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411 http://www.ncbi.nlm.nih.gov/pubmed/23612371 https://doi.org/10.3390/md11041399 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411 http://www.ncbi.nlm.nih.gov/pubmed/23612371 http://dx.doi.org/10.3390/md11041399 © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2013 ftpubmed https://doi.org/10.3390/md11041399 2013-09-05T02:12:03Z A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. Text Antarc* Antarctic PubMed Central (PMC) Antarctic Marine Drugs 11 4 1399 1408
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Article
spellingShingle Article
Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
topic_facet Article
description A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines.
format Text
author Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_facet Wu, Guangwei
Lin, Aiqun
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_sort Wu, Guangwei
title Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_short Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_fullStr Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_full_unstemmed Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus, Penicillium sp. PR19N-1
title_sort four new chloro-eremophilane sesquiterpenes from an antarctic deep-sea derived fungus, penicillium sp. pr19n-1
publisher MDPI
publishDate 2013
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411
http://www.ncbi.nlm.nih.gov/pubmed/23612371
https://doi.org/10.3390/md11041399
geographic Antarctic
geographic_facet Antarctic
genre Antarc*
Antarctic
genre_facet Antarc*
Antarctic
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705411
http://www.ncbi.nlm.nih.gov/pubmed/23612371
http://dx.doi.org/10.3390/md11041399
op_rights © 2013 by the authors; licensee MDPI, Basel, Switzerland.
http://creativecommons.org/licenses/by/3.0/
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
op_rightsnorm CC-BY
op_doi https://doi.org/10.3390/md11041399
container_title Marine Drugs
container_volume 11
container_issue 4
container_start_page 1399
op_container_end_page 1408
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