Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort
Killer immunoglobulin-like receptors (KIR) on natural killer (NK) cells interact with other immune cells to monitor the immune system and combat infectious diseases, such as tuberculosis (TB). The balance of activating and inhibiting KIR interactions helps determine the NK cell response. In order to...
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ftpubmed:oai:pubmedcentral.nih.gov:3701593 2023-05-15T16:14:26+02:00 Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort Braun, Kali Larcombe, Linda Orr, Pamela Nickerson, Peter Wolfe, Joyce Sharma, Meenu 2013-07-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701593 http://www.ncbi.nlm.nih.gov/pubmed/23861818 https://doi.org/10.1371/journal.pone.0067842 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701593 http://www.ncbi.nlm.nih.gov/pubmed/23861818 http://dx.doi.org/10.1371/journal.pone.0067842 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2013 ftpubmed https://doi.org/10.1371/journal.pone.0067842 2013-09-05T02:01:16Z Killer immunoglobulin-like receptors (KIR) on natural killer (NK) cells interact with other immune cells to monitor the immune system and combat infectious diseases, such as tuberculosis (TB). The balance of activating and inhibiting KIR interactions helps determine the NK cell response. In order to examine the enrichment or depletion of KIRs as well as to explore the association between TB status and inhibitory/stimulatory KIR haplotypes, we performed KIR genotyping on samples from 93 Canadian First Nations (Dene, Cree, and Ojibwa) individuals from Manitoba with active, latent, or no TB infection, and 75 uninfected Caucasian controls. There were significant differences in KIR genes between Caucasians and First Nations samples and also between the First Nations ethnocultural groups (Dene, Cree, and Ojibwa). When analyzing ethnicity and tuberculosis status in the study population, it appears that the KIR profile and centromeric haplotype are more predictive than the presence or absence of individual genes. Specifically, the decreased presence of haplotype B centromeric genes and increased presence of centromeric-AA haplotypes in First Nations may contribute to an inhibitory immune profile, explaining the high rates of TB in this population. Text First Nations PubMed Central (PMC) PLoS ONE 8 7 e67842 |
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Research Article Braun, Kali Larcombe, Linda Orr, Pamela Nickerson, Peter Wolfe, Joyce Sharma, Meenu Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
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Research Article |
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Killer immunoglobulin-like receptors (KIR) on natural killer (NK) cells interact with other immune cells to monitor the immune system and combat infectious diseases, such as tuberculosis (TB). The balance of activating and inhibiting KIR interactions helps determine the NK cell response. In order to examine the enrichment or depletion of KIRs as well as to explore the association between TB status and inhibitory/stimulatory KIR haplotypes, we performed KIR genotyping on samples from 93 Canadian First Nations (Dene, Cree, and Ojibwa) individuals from Manitoba with active, latent, or no TB infection, and 75 uninfected Caucasian controls. There were significant differences in KIR genes between Caucasians and First Nations samples and also between the First Nations ethnocultural groups (Dene, Cree, and Ojibwa). When analyzing ethnicity and tuberculosis status in the study population, it appears that the KIR profile and centromeric haplotype are more predictive than the presence or absence of individual genes. Specifically, the decreased presence of haplotype B centromeric genes and increased presence of centromeric-AA haplotypes in First Nations may contribute to an inhibitory immune profile, explaining the high rates of TB in this population. |
format |
Text |
author |
Braun, Kali Larcombe, Linda Orr, Pamela Nickerson, Peter Wolfe, Joyce Sharma, Meenu |
author_facet |
Braun, Kali Larcombe, Linda Orr, Pamela Nickerson, Peter Wolfe, Joyce Sharma, Meenu |
author_sort |
Braun, Kali |
title |
Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
title_short |
Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
title_full |
Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
title_fullStr |
Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
title_full_unstemmed |
Killer Immunoglobulin-Like Receptor (KIR) Centromeric-AA Haplotype Is Associated with Ethnicity and Tuberculosis Disease in a Canadian First Nations Cohort |
title_sort |
killer immunoglobulin-like receptor (kir) centromeric-aa haplotype is associated with ethnicity and tuberculosis disease in a canadian first nations cohort |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701593 http://www.ncbi.nlm.nih.gov/pubmed/23861818 https://doi.org/10.1371/journal.pone.0067842 |
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First Nations |
genre_facet |
First Nations |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701593 http://www.ncbi.nlm.nih.gov/pubmed/23861818 http://dx.doi.org/10.1371/journal.pone.0067842 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0067842 |
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PLoS ONE |
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8 |
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e67842 |
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1766000239038169088 |