Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury
Prenatal exposure to methylmercury can cause both neurobehavioral deficits and neurophysiological changes. However, evidence of neurotoxic effects within the visual nervous system is inconsistent, possibly due to incomplete statistical adjustment for beneficial nutritional factors. We evaluated the...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696435 http://www.ncbi.nlm.nih.gov/pubmed/23548974 https://doi.org/10.1016/j.neuro.2013.03.009 |
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ftpubmed:oai:pubmedcentral.nih.gov:3696435 2023-05-15T16:10:54+02:00 Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury Yorifuji, Takashi Murata, Katsuyuki Bjerve, Kristian S. Choi, Anna L Weihe, Pal Grandjean, Philippe 2013-03-30 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696435 http://www.ncbi.nlm.nih.gov/pubmed/23548974 https://doi.org/10.1016/j.neuro.2013.03.009 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/23548974 http://dx.doi.org/10.1016/j.neuro.2013.03.009 © 2013 Published by Elsevier Inc. Article Text 2013 ftpubmed https://doi.org/10.1016/j.neuro.2013.03.009 2014-07-06T00:43:42Z Prenatal exposure to methylmercury can cause both neurobehavioral deficits and neurophysiological changes. However, evidence of neurotoxic effects within the visual nervous system is inconsistent, possibly due to incomplete statistical adjustment for beneficial nutritional factors. We evaluated the effect of prenatal methylmercury exposure on visual evoked potential (VEP) latencies in Faroese children with elevated prenatal methylmercury exposure. A cohort of 182 singleton term births was assembled in the Faroe Islands during 1994–1995. At age 7 years, VEP tracings were obtained from 139 cohort subjects after exclusion of subjects with abnormal vision conditions. We used multiple regression analysis to evaluate the association of mercury concentrations in cord blood and maternal hair at parturition with VEP latencies after adjustment for potential confounders that included the cord-serum phospholipid concentration of n-3 polyunsaturated fatty acids (PUFAs) and the duration of breastfeeding. Unadjusted correlations between mercury exposure and VEP latencies were equivocal. Multiple regression models showed that increased mercury concentrations, especially in maternal hair, were associated with delayed latencies for VEP peak N145. After covariate adjustment, a delay of 2.22 ms (p=0.02) was seen for each doubling of the mercury concentration in maternal hair. In agreement with neuropsychological findings, the present study suggests that prenatal methylmercury exposure may have an adverse effect on VEP findings despite the absence of clinical toxicity to the visual system. However, this association was apparent only after adjustment for n-3 PUFA status. Text Faroe Islands PubMed Central (PMC) Faroe Islands NeuroToxicology 37 15 18 |
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Article Yorifuji, Takashi Murata, Katsuyuki Bjerve, Kristian S. Choi, Anna L Weihe, Pal Grandjean, Philippe Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
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Prenatal exposure to methylmercury can cause both neurobehavioral deficits and neurophysiological changes. However, evidence of neurotoxic effects within the visual nervous system is inconsistent, possibly due to incomplete statistical adjustment for beneficial nutritional factors. We evaluated the effect of prenatal methylmercury exposure on visual evoked potential (VEP) latencies in Faroese children with elevated prenatal methylmercury exposure. A cohort of 182 singleton term births was assembled in the Faroe Islands during 1994–1995. At age 7 years, VEP tracings were obtained from 139 cohort subjects after exclusion of subjects with abnormal vision conditions. We used multiple regression analysis to evaluate the association of mercury concentrations in cord blood and maternal hair at parturition with VEP latencies after adjustment for potential confounders that included the cord-serum phospholipid concentration of n-3 polyunsaturated fatty acids (PUFAs) and the duration of breastfeeding. Unadjusted correlations between mercury exposure and VEP latencies were equivocal. Multiple regression models showed that increased mercury concentrations, especially in maternal hair, were associated with delayed latencies for VEP peak N145. After covariate adjustment, a delay of 2.22 ms (p=0.02) was seen for each doubling of the mercury concentration in maternal hair. In agreement with neuropsychological findings, the present study suggests that prenatal methylmercury exposure may have an adverse effect on VEP findings despite the absence of clinical toxicity to the visual system. However, this association was apparent only after adjustment for n-3 PUFA status. |
format |
Text |
author |
Yorifuji, Takashi Murata, Katsuyuki Bjerve, Kristian S. Choi, Anna L Weihe, Pal Grandjean, Philippe |
author_facet |
Yorifuji, Takashi Murata, Katsuyuki Bjerve, Kristian S. Choi, Anna L Weihe, Pal Grandjean, Philippe |
author_sort |
Yorifuji, Takashi |
title |
Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
title_short |
Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
title_full |
Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
title_fullStr |
Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
title_full_unstemmed |
Visual Evoked Potentials in Children Prenatally Exposed to Methylmercury |
title_sort |
visual evoked potentials in children prenatally exposed to methylmercury |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696435 http://www.ncbi.nlm.nih.gov/pubmed/23548974 https://doi.org/10.1016/j.neuro.2013.03.009 |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/23548974 http://dx.doi.org/10.1016/j.neuro.2013.03.009 |
op_rights |
© 2013 Published by Elsevier Inc. |
op_doi |
https://doi.org/10.1016/j.neuro.2013.03.009 |
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NeuroToxicology |
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