The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis
Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) in young adults. The proinflammatory cytokines such as interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) which are known to be produced by inflammatory...
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ftpubmed:oai:pubmedcentral.nih.gov:3671506 2023-05-15T15:08:17+02:00 The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis Poyraz, Turan Idiman, Egemen Uysal, Sezer Iyilikci, Leyla Özakbaş, Serkan Coskuner Poyraz, Esra Idiman, Fethi 2013-05-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671506 http://www.ncbi.nlm.nih.gov/pubmed/23762603 https://doi.org/10.1155/2013/964572 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671506 http://www.ncbi.nlm.nih.gov/pubmed/23762603 http://dx.doi.org/10.1155/2013/964572 Copyright © 2013 Turan Poyraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Clinical Study Text 2013 ftpubmed https://doi.org/10.1155/2013/964572 2013-09-05T00:35:34Z Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) in young adults. The proinflammatory cytokines such as interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) which are known to be produced by inflammatory cells play a key role in the pathogenesis of MS. Some metabolic changes may have an effect on axonal transmission, and white blood cells NO and other inflammatory mediators such as cytokines may be affected from cooling process. In this study, we evaluated the effects of body cooling procedure on proinflammatory cytokines such as TNF-α, IFN-γ, and NO levels. Twenty patients with MS were evaluated. Thirteen of the patients were women, 7 were men (mean age: 33.6 ± 7.5 yrs.). Body temperature was reduced by an average of 1°C approximately in 1 hour with using the “Medivance Arctic Sun Temperature Management System” device. In our study, the decrease in TNF-α, IFN-γ levels after the cooling procedure has no statistical significance, whereas the decrease in the mean level of NO level after the cooling procedure is 4.63 ± 7.4 μmol/L which has statistical significance (P = 0.002). These results suggested that the decrease in NO level improves conduction block in demyelinated axonal segments after cooling procedure in multiple sclerosis. Text Arctic PubMed Central (PMC) Arctic ISRN Neurology 2013 1 6 |
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Clinical Study Poyraz, Turan Idiman, Egemen Uysal, Sezer Iyilikci, Leyla Özakbaş, Serkan Coskuner Poyraz, Esra Idiman, Fethi The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
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Clinical Study |
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Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) in young adults. The proinflammatory cytokines such as interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) which are known to be produced by inflammatory cells play a key role in the pathogenesis of MS. Some metabolic changes may have an effect on axonal transmission, and white blood cells NO and other inflammatory mediators such as cytokines may be affected from cooling process. In this study, we evaluated the effects of body cooling procedure on proinflammatory cytokines such as TNF-α, IFN-γ, and NO levels. Twenty patients with MS were evaluated. Thirteen of the patients were women, 7 were men (mean age: 33.6 ± 7.5 yrs.). Body temperature was reduced by an average of 1°C approximately in 1 hour with using the “Medivance Arctic Sun Temperature Management System” device. In our study, the decrease in TNF-α, IFN-γ levels after the cooling procedure has no statistical significance, whereas the decrease in the mean level of NO level after the cooling procedure is 4.63 ± 7.4 μmol/L which has statistical significance (P = 0.002). These results suggested that the decrease in NO level improves conduction block in demyelinated axonal segments after cooling procedure in multiple sclerosis. |
format |
Text |
author |
Poyraz, Turan Idiman, Egemen Uysal, Sezer Iyilikci, Leyla Özakbaş, Serkan Coskuner Poyraz, Esra Idiman, Fethi |
author_facet |
Poyraz, Turan Idiman, Egemen Uysal, Sezer Iyilikci, Leyla Özakbaş, Serkan Coskuner Poyraz, Esra Idiman, Fethi |
author_sort |
Poyraz, Turan |
title |
The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
title_short |
The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
title_full |
The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
title_fullStr |
The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
title_full_unstemmed |
The Cooling Effect on Proinflammatory Cytokines Interferon-Gamma, Tumor Necrosis Factor-Alpha, and Nitric Oxide in Patients with Multiple Sclerosis |
title_sort |
cooling effect on proinflammatory cytokines interferon-gamma, tumor necrosis factor-alpha, and nitric oxide in patients with multiple sclerosis |
publisher |
Hindawi Publishing Corporation |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671506 http://www.ncbi.nlm.nih.gov/pubmed/23762603 https://doi.org/10.1155/2013/964572 |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671506 http://www.ncbi.nlm.nih.gov/pubmed/23762603 http://dx.doi.org/10.1155/2013/964572 |
op_rights |
Copyright © 2013 Turan Poyraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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CC-BY |
op_doi |
https://doi.org/10.1155/2013/964572 |
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ISRN Neurology |
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2013 |
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6 |
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