Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain
We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and al...
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ftpubmed:oai:pubmedcentral.nih.gov:3646885 2023-05-15T18:09:51+02:00 Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain O'Farrell, Brian Benzie, John A. H. McGinnity, Phil de Eyto, Elvira Dillane, Eileen Coughlan, James Cross, Tom F. 2013-05-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646885 http://www.ncbi.nlm.nih.gov/pubmed/23667568 https://doi.org/10.1371/journal.pone.0063035 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646885 http://www.ncbi.nlm.nih.gov/pubmed/23667568 http://dx.doi.org/10.1371/journal.pone.0063035 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2013 ftpubmed https://doi.org/10.1371/journal.pone.0063035 2013-09-04T23:25:59Z We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and allelic divergence is much higher than that noted previously for co-habiting S. salar. Recombination was found to be important to population-level divergence. The α1 and α2 domains of UBA demonstrate ancient lineages but novel lineages are also identified at both domains in this work. We also find examples of recombination between UBA and the non-classical locus, ULA. Evidence for strong diversifying selection was found at a discrete suite of S. trutta UBA amino acid sites. The pattern was found to contrast with that found in re-analysed UBA data from an artificially stocked S. trutta population. Text Salmo salar PubMed Central (PMC) Ula ENVELOPE(-57.139,-57.139,-64.086,-64.086) PLoS ONE 8 5 e63035 |
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Research Article O'Farrell, Brian Benzie, John A. H. McGinnity, Phil de Eyto, Elvira Dillane, Eileen Coughlan, James Cross, Tom F. Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
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Research Article |
description |
We tested how variation at a gene of adaptive importance, MHC class I (UBA), in a wild, endemic Salmo trutta population compared to that in both a previously studied non-native S. trutta population and a co-habiting Salmo salar population (a sister species). High allelic diversity is observed and allelic divergence is much higher than that noted previously for co-habiting S. salar. Recombination was found to be important to population-level divergence. The α1 and α2 domains of UBA demonstrate ancient lineages but novel lineages are also identified at both domains in this work. We also find examples of recombination between UBA and the non-classical locus, ULA. Evidence for strong diversifying selection was found at a discrete suite of S. trutta UBA amino acid sites. The pattern was found to contrast with that found in re-analysed UBA data from an artificially stocked S. trutta population. |
format |
Text |
author |
O'Farrell, Brian Benzie, John A. H. McGinnity, Phil de Eyto, Elvira Dillane, Eileen Coughlan, James Cross, Tom F. |
author_facet |
O'Farrell, Brian Benzie, John A. H. McGinnity, Phil de Eyto, Elvira Dillane, Eileen Coughlan, James Cross, Tom F. |
author_sort |
O'Farrell, Brian |
title |
Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
title_short |
Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
title_full |
Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
title_fullStr |
Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
title_full_unstemmed |
Selection and Phylogenetics of Salmonid MHC Class I: Wild Brown Trout (Salmo trutta) Differ from a Non-Native Introduced Strain |
title_sort |
selection and phylogenetics of salmonid mhc class i: wild brown trout (salmo trutta) differ from a non-native introduced strain |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646885 http://www.ncbi.nlm.nih.gov/pubmed/23667568 https://doi.org/10.1371/journal.pone.0063035 |
long_lat |
ENVELOPE(-57.139,-57.139,-64.086,-64.086) |
geographic |
Ula |
geographic_facet |
Ula |
genre |
Salmo salar |
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Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646885 http://www.ncbi.nlm.nih.gov/pubmed/23667568 http://dx.doi.org/10.1371/journal.pone.0063035 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0063035 |
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PLoS ONE |
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8 |
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5 |
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e63035 |
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1766182536636006400 |