Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as bi...

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Published in:Marine Drugs
Main Authors: Dinica, Rodica Mihaela, Furdui, Bianca, Ghinea, Ioana Otilia, Bahrim, Gabriela, Bonte, Simon, Demeunynck, Martine
Format: Text
Language:English
Published: MDPI 2013
Subjects:
Communication
Antarc*
Antarctica
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390
http://www.ncbi.nlm.nih.gov/pubmed/23389089
https://doi.org/10.3390/md11020431
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record_format openpolar
spelling ftpubmed:oai:pubmedcentral.nih.gov:3640390 2023-05-15T14:02:56+02:00 Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases Dinica, Rodica Mihaela Furdui, Bianca Ghinea, Ioana Otilia Bahrim, Gabriela Bonte, Simon Demeunynck, Martine 2013-02-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390 http://www.ncbi.nlm.nih.gov/pubmed/23389089 https://doi.org/10.3390/md11020431 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390 http://www.ncbi.nlm.nih.gov/pubmed/23389089 http://dx.doi.org/10.3390/md11020431 © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Communication Text 2013 ftpubmed https://doi.org/10.3390/md11020431 2013-09-04T23:07:56Z Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time. Text Antarc* Antarctica PubMed Central (PMC) Marine Drugs 11 12 431 439
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Communication
spellingShingle Communication
Dinica, Rodica Mihaela
Furdui, Bianca
Ghinea, Ioana Otilia
Bahrim, Gabriela
Bonte, Simon
Demeunynck, Martine
Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
topic_facet Communication
description Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.
format Text
author Dinica, Rodica Mihaela
Furdui, Bianca
Ghinea, Ioana Otilia
Bahrim, Gabriela
Bonte, Simon
Demeunynck, Martine
author_facet Dinica, Rodica Mihaela
Furdui, Bianca
Ghinea, Ioana Otilia
Bahrim, Gabriela
Bonte, Simon
Demeunynck, Martine
author_sort Dinica, Rodica Mihaela
title Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
title_short Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
title_full Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
title_fullStr Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
title_full_unstemmed Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases
title_sort novel one-pot green synthesis of indolizines biocatalysed by candida antarctica lipases
publisher MDPI
publishDate 2013
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390
http://www.ncbi.nlm.nih.gov/pubmed/23389089
https://doi.org/10.3390/md11020431
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390
http://www.ncbi.nlm.nih.gov/pubmed/23389089
http://dx.doi.org/10.3390/md11020431
op_rights © 2013 by the authors; licensee MDPI, Basel, Switzerland.
http://creativecommons.org/licenses/by/3.0/
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
op_rightsnorm CC-BY
op_doi https://doi.org/10.3390/md11020431
container_title Marine Drugs
container_volume 11
container_issue 12
container_start_page 431
op_container_end_page 439
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