Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype?
Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves are not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We c...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623481 http://www.ncbi.nlm.nih.gov/pubmed/23051979 https://doi.org/10.1093/gerona/gls193 |
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ftpubmed:oai:pubmedcentral.nih.gov:3623481 2023-05-15T15:22:28+02:00 Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? Ungvari, Zoltan Sosnowska, Danuta Mason, Jeffrey B. Gruber, Heike Lee, Star W. Schwartz, Tonia S. Brown, Marishka K. Storm, Nadia J. Fortney, Kristen Sowa, Jessica Byrne, Alexandra B. Kurz, Tino Levy, Erik Sonntag, William E. Austad, Steven N. Csiszar, Anna Ridgway, Iain 2013-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623481 http://www.ncbi.nlm.nih.gov/pubmed/23051979 https://doi.org/10.1093/gerona/gls193 en eng Oxford University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/23051979 http://dx.doi.org/10.1093/gerona/gls193 © The Author 2012. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Original Article Text 2013 ftpubmed https://doi.org/10.1093/gerona/gls193 2014-05-04T00:32:10Z Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves are not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We contrasted resistance (in terms of organismal mortality) to genotoxic stresses (including topoisomerase inhibitors, agents that cross-link DNA or impair genomic integrity through DNA alkylation or methylation) and to mitochondrial oxidative stressors in three bivalve mollusc species with dramatically differing life spans: Arctica islandica (ocean quahog), Mercenaria mercenaria (northern quahog), and the Atlantic bay scallop, Argopecten irradians irradians (maximum species life spans: >500, >100, and ~2 years, respectively). With all stressors, the short-lived A i irradians were significantly less resistant than the two longer lived species. Arctica islandica were consistently more resistant than M mercenaria to mortality induced by oxidative stressors as well as DNA methylating agent nitrogen mustard and the DNA alkylating agent methyl methanesulfonate. The same trend was not observed for genotoxic agents that act through cross-linking DNA. In contrast, M mercenaria tended to be more resistant to epirubicin and genotoxic stressors, which cause DNA damage by inhibiting topoisomerases. To our knowledge, this is the first study comparing resistance to genotoxic stressors in bivalve mollusc species with disparate longevities. In line with previous studies of comparative stress resistance and longevity, our data extends, at least in part, the evidence for the hypothesis that an association exists between longevity and a general resistance to multiplex stressors, not solely oxidative stress. This work also provides justification for further investigation into the interspecies differences in stress response signatures induced by a diverse array of stressors in short-lived and long-lived bivalves, including ... Text Arctica islandica Ocean quahog PubMed Central (PMC) The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 68 5 521 529 |
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English |
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Original Article |
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Original Article Ungvari, Zoltan Sosnowska, Danuta Mason, Jeffrey B. Gruber, Heike Lee, Star W. Schwartz, Tonia S. Brown, Marishka K. Storm, Nadia J. Fortney, Kristen Sowa, Jessica Byrne, Alexandra B. Kurz, Tino Levy, Erik Sonntag, William E. Austad, Steven N. Csiszar, Anna Ridgway, Iain Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
topic_facet |
Original Article |
description |
Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves are not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We contrasted resistance (in terms of organismal mortality) to genotoxic stresses (including topoisomerase inhibitors, agents that cross-link DNA or impair genomic integrity through DNA alkylation or methylation) and to mitochondrial oxidative stressors in three bivalve mollusc species with dramatically differing life spans: Arctica islandica (ocean quahog), Mercenaria mercenaria (northern quahog), and the Atlantic bay scallop, Argopecten irradians irradians (maximum species life spans: >500, >100, and ~2 years, respectively). With all stressors, the short-lived A i irradians were significantly less resistant than the two longer lived species. Arctica islandica were consistently more resistant than M mercenaria to mortality induced by oxidative stressors as well as DNA methylating agent nitrogen mustard and the DNA alkylating agent methyl methanesulfonate. The same trend was not observed for genotoxic agents that act through cross-linking DNA. In contrast, M mercenaria tended to be more resistant to epirubicin and genotoxic stressors, which cause DNA damage by inhibiting topoisomerases. To our knowledge, this is the first study comparing resistance to genotoxic stressors in bivalve mollusc species with disparate longevities. In line with previous studies of comparative stress resistance and longevity, our data extends, at least in part, the evidence for the hypothesis that an association exists between longevity and a general resistance to multiplex stressors, not solely oxidative stress. This work also provides justification for further investigation into the interspecies differences in stress response signatures induced by a diverse array of stressors in short-lived and long-lived bivalves, including ... |
format |
Text |
author |
Ungvari, Zoltan Sosnowska, Danuta Mason, Jeffrey B. Gruber, Heike Lee, Star W. Schwartz, Tonia S. Brown, Marishka K. Storm, Nadia J. Fortney, Kristen Sowa, Jessica Byrne, Alexandra B. Kurz, Tino Levy, Erik Sonntag, William E. Austad, Steven N. Csiszar, Anna Ridgway, Iain |
author_facet |
Ungvari, Zoltan Sosnowska, Danuta Mason, Jeffrey B. Gruber, Heike Lee, Star W. Schwartz, Tonia S. Brown, Marishka K. Storm, Nadia J. Fortney, Kristen Sowa, Jessica Byrne, Alexandra B. Kurz, Tino Levy, Erik Sonntag, William E. Austad, Steven N. Csiszar, Anna Ridgway, Iain |
author_sort |
Ungvari, Zoltan |
title |
Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
title_short |
Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
title_full |
Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
title_fullStr |
Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
title_full_unstemmed |
Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype? |
title_sort |
resistance to genotoxic stresses in arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype? |
publisher |
Oxford University Press |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623481 http://www.ncbi.nlm.nih.gov/pubmed/23051979 https://doi.org/10.1093/gerona/gls193 |
genre |
Arctica islandica Ocean quahog |
genre_facet |
Arctica islandica Ocean quahog |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC http://www.ncbi.nlm.nih.gov/pubmed/23051979 http://dx.doi.org/10.1093/gerona/gls193 |
op_rights |
© The Author 2012. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
op_doi |
https://doi.org/10.1093/gerona/gls193 |
container_title |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
container_volume |
68 |
container_issue |
5 |
container_start_page |
521 |
op_container_end_page |
529 |
_version_ |
1766353130161700864 |