Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population
The polymorphisms in the human leukocyte antigen (HLA) region are powerful tool for studying human evolutionary processes. We investigated genetic structure of Japanese by using five-locus HLA genotypes (HLA-A, -B, -C, -DRB1, and -DPB1) of 2,005 individuals from 10 regions of Japan. We found a signi...
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ftpubmed:oai:pubmedcentral.nih.gov:3618337 2023-05-15T15:10:32+02:00 Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population Nakaoka, Hirofumi Mitsunaga, Shigeki Hosomichi, Kazuyoshi Shyh-Yuh, Liou Sawamoto, Taiji Fujiwara, Tsutomu Tsutsui, Naohisa Suematsu, Koji Shinagawa, Akira Inoko, Hidetoshi Inoue, Ituro 2013-04-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618337 http://www.ncbi.nlm.nih.gov/pubmed/23577161 https://doi.org/10.1371/journal.pone.0060793 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618337 http://www.ncbi.nlm.nih.gov/pubmed/23577161 http://dx.doi.org/10.1371/journal.pone.0060793 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2013 ftpubmed https://doi.org/10.1371/journal.pone.0060793 2013-09-04T22:08:07Z The polymorphisms in the human leukocyte antigen (HLA) region are powerful tool for studying human evolutionary processes. We investigated genetic structure of Japanese by using five-locus HLA genotypes (HLA-A, -B, -C, -DRB1, and -DPB1) of 2,005 individuals from 10 regions of Japan. We found a significant level of population substructure in Japanese; particularly the differentiation between Okinawa Island and mainland Japanese. By using a plot of the principal component scores, we identified ancestry informative alleles associated with the underlying population substructure. We examined extent of linkage disequilibrium (LD) between pairs of HLA alleles on the haplotypes that were differentiated among regions. The LDs were strong and weak for pairs of HLA alleles characterized by low and high frequencies in Okinawa Island, respectively. The five-locus haplotypes whose alleles exhibit strong LD were unique to Japanese and South Korean, suggesting that these haplotypes had been recently derived from the Korean Peninsula. The alleles characterized by high frequency in Japanese compared to South Korean formed segmented three-locus haplotype that was commonly found in Aleuts, Eskimos, and North- and Meso-Americans but not observed in Korean and Chinese. The serologically equivalent haplotype was found in Orchid Island in Taiwan, Mongol, Siberia, and Arctic regions. It suggests that early Japanese who existed prior to the migration wave from the Korean Peninsula shared ancestry with northern Asian who moved to the New World via the Bering Strait land bridge. These results may support the admixture model for peopling of Japanese Archipelago. Text Arctic Bering Strait eskimo* Siberia PubMed Central (PMC) Arctic Bering Strait PLoS ONE 8 4 e60793 |
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Research Article |
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Research Article Nakaoka, Hirofumi Mitsunaga, Shigeki Hosomichi, Kazuyoshi Shyh-Yuh, Liou Sawamoto, Taiji Fujiwara, Tsutomu Tsutsui, Naohisa Suematsu, Koji Shinagawa, Akira Inoko, Hidetoshi Inoue, Ituro Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
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Research Article |
description |
The polymorphisms in the human leukocyte antigen (HLA) region are powerful tool for studying human evolutionary processes. We investigated genetic structure of Japanese by using five-locus HLA genotypes (HLA-A, -B, -C, -DRB1, and -DPB1) of 2,005 individuals from 10 regions of Japan. We found a significant level of population substructure in Japanese; particularly the differentiation between Okinawa Island and mainland Japanese. By using a plot of the principal component scores, we identified ancestry informative alleles associated with the underlying population substructure. We examined extent of linkage disequilibrium (LD) between pairs of HLA alleles on the haplotypes that were differentiated among regions. The LDs were strong and weak for pairs of HLA alleles characterized by low and high frequencies in Okinawa Island, respectively. The five-locus haplotypes whose alleles exhibit strong LD were unique to Japanese and South Korean, suggesting that these haplotypes had been recently derived from the Korean Peninsula. The alleles characterized by high frequency in Japanese compared to South Korean formed segmented three-locus haplotype that was commonly found in Aleuts, Eskimos, and North- and Meso-Americans but not observed in Korean and Chinese. The serologically equivalent haplotype was found in Orchid Island in Taiwan, Mongol, Siberia, and Arctic regions. It suggests that early Japanese who existed prior to the migration wave from the Korean Peninsula shared ancestry with northern Asian who moved to the New World via the Bering Strait land bridge. These results may support the admixture model for peopling of Japanese Archipelago. |
format |
Text |
author |
Nakaoka, Hirofumi Mitsunaga, Shigeki Hosomichi, Kazuyoshi Shyh-Yuh, Liou Sawamoto, Taiji Fujiwara, Tsutomu Tsutsui, Naohisa Suematsu, Koji Shinagawa, Akira Inoko, Hidetoshi Inoue, Ituro |
author_facet |
Nakaoka, Hirofumi Mitsunaga, Shigeki Hosomichi, Kazuyoshi Shyh-Yuh, Liou Sawamoto, Taiji Fujiwara, Tsutomu Tsutsui, Naohisa Suematsu, Koji Shinagawa, Akira Inoko, Hidetoshi Inoue, Ituro |
author_sort |
Nakaoka, Hirofumi |
title |
Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
title_short |
Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
title_full |
Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
title_fullStr |
Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
title_full_unstemmed |
Detection of Ancestry Informative HLA Alleles Confirms the Admixed Origins of Japanese Population |
title_sort |
detection of ancestry informative hla alleles confirms the admixed origins of japanese population |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618337 http://www.ncbi.nlm.nih.gov/pubmed/23577161 https://doi.org/10.1371/journal.pone.0060793 |
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Arctic Bering Strait |
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Arctic Bering Strait |
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Arctic Bering Strait eskimo* Siberia |
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Arctic Bering Strait eskimo* Siberia |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618337 http://www.ncbi.nlm.nih.gov/pubmed/23577161 http://dx.doi.org/10.1371/journal.pone.0060793 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0060793 |
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e60793 |
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