Potential Use of Atlantic Cod Trypsin in Biomedicine
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be...
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ftpubmed:oai:pubmedcentral.nih.gov:3600245 2023-05-15T15:27:12+02:00 Potential Use of Atlantic Cod Trypsin in Biomedicine Gudmundsdóttir, Ágústa Hilmarsson, Hilmar Stefansson, Bjarki 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600245 http://www.ncbi.nlm.nih.gov/pubmed/23555095 https://doi.org/10.1155/2013/749078 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600245 http://www.ncbi.nlm.nih.gov/pubmed/23555095 http://dx.doi.org/10.1155/2013/749078 Copyright © 2013 Ágústa Gudmundsdóttir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Review Article Text 2013 ftpubmed https://doi.org/10.1155/2013/749078 2013-09-04T21:16:21Z Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. Text atlantic cod Gadus morhua PubMed Central (PMC) BioMed Research International 2013 1 11 |
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Review Article Gudmundsdóttir, Ágústa Hilmarsson, Hilmar Stefansson, Bjarki Potential Use of Atlantic Cod Trypsin in Biomedicine |
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Review Article |
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Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. |
format |
Text |
author |
Gudmundsdóttir, Ágústa Hilmarsson, Hilmar Stefansson, Bjarki |
author_facet |
Gudmundsdóttir, Ágústa Hilmarsson, Hilmar Stefansson, Bjarki |
author_sort |
Gudmundsdóttir, Ágústa |
title |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_short |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_fullStr |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full_unstemmed |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_sort |
potential use of atlantic cod trypsin in biomedicine |
publisher |
Hindawi Publishing Corporation |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600245 http://www.ncbi.nlm.nih.gov/pubmed/23555095 https://doi.org/10.1155/2013/749078 |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600245 http://www.ncbi.nlm.nih.gov/pubmed/23555095 http://dx.doi.org/10.1155/2013/749078 |
op_rights |
Copyright © 2013 Ágústa Gudmundsdóttir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2013/749078 |
container_title |
BioMed Research International |
container_volume |
2013 |
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1 |
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11 |
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1766357647380971520 |