Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intrac...
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ftpubmed:oai:pubmedcentral.nih.gov:3588204 2023-05-15T16:06:03+02:00 Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress Kim, Ki Cheon Kim, Daeshin Kim, Sang Cheol Jung, Eunsun Park, Deokhoon Hyun, Jin Won 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588204 http://www.ncbi.nlm.nih.gov/pubmed/23476710 https://doi.org/10.1155/2013/983609 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588204 http://www.ncbi.nlm.nih.gov/pubmed/23476710 http://dx.doi.org/10.1155/2013/983609 Copyright © 2013 Ki Cheon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Research Article Text 2013 ftpubmed https://doi.org/10.1155/2013/983609 2013-09-04T20:39:25Z This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. Text Empetrum nigrum PubMed Central (PMC) Evidence-Based Complementary and Alternative Medicine 2013 1 10 |
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Research Article Kim, Ki Cheon Kim, Daeshin Kim, Sang Cheol Jung, Eunsun Park, Deokhoon Hyun, Jin Won Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
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Research Article |
description |
This study focused on the protective actions of Empetrum nigrum against ultraviolet B (UVB) radiation in human HaCaT keratinocytes. An ethyl acetate extract of E. nigrum (ENE) increased cell viability decreased by exposure to UVB rays. ENE also absorbed UVB radiation and scavenged UVB-induced intracellular reactive oxygen species (ROS) in HaCaT keratinocytes. In addition, ENE shielded HaCaT keratinocytes from damage to cellular components (e.g., peroxidation of lipids, modification of proteins, and breakage of DNA strands) following UVB irradiation. Furthermore, ENE protected against UVB-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies and sub-G1 hypodiploid cells, as well as by the recovery of mitochondrial membrane potential. The results of the current study therefore suggest that ENE safeguards human keratinocytes against UVB-induced cellular damage via the absorption of UVB ray and scavenging of UVB-generated ROS. |
format |
Text |
author |
Kim, Ki Cheon Kim, Daeshin Kim, Sang Cheol Jung, Eunsun Park, Deokhoon Hyun, Jin Won |
author_facet |
Kim, Ki Cheon Kim, Daeshin Kim, Sang Cheol Jung, Eunsun Park, Deokhoon Hyun, Jin Won |
author_sort |
Kim, Ki Cheon |
title |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_short |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_fullStr |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_full_unstemmed |
Empetrum nigrum var. japonicum Extract Suppresses Ultraviolet B-Induced Cell Damage via Absorption of Radiation and Inhibition of Oxidative Stress |
title_sort |
empetrum nigrum var. japonicum extract suppresses ultraviolet b-induced cell damage via absorption of radiation and inhibition of oxidative stress |
publisher |
Hindawi Publishing Corporation |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588204 http://www.ncbi.nlm.nih.gov/pubmed/23476710 https://doi.org/10.1155/2013/983609 |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588204 http://www.ncbi.nlm.nih.gov/pubmed/23476710 http://dx.doi.org/10.1155/2013/983609 |
op_rights |
Copyright © 2013 Ki Cheon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1155/2013/983609 |
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Evidence-Based Complementary and Alternative Medicine |
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2013 |
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1 |
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10 |
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1766401969333731328 |