Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially
Enhanced omega-3 fatty acid (n-3) intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish intake on plasma le...
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ftpubmed:oai:pubmedcentral.nih.gov:3572904 2023-05-15T15:30:24+02:00 Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially Raatz, Susan K. Rosenberger, Thad A. Johnson, LuAnn K. Wolters, William W. Burr, Gary S Picklo, Matthew J. 2013-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572904 http://www.ncbi.nlm.nih.gov/pubmed/23351633 https://doi.org/10.1016/j.jand.2012.09.022 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572904 http://www.ncbi.nlm.nih.gov/pubmed/23351633 http://dx.doi.org/10.1016/j.jand.2012.09.022 © 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. Article Text 2013 ftpubmed https://doi.org/10.1016/j.jand.2012.09.022 2014-02-02T01:39:32Z Enhanced omega-3 fatty acid (n-3) intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish intake on plasma levels of n-3 fatty acids. To compare the effects of different doses of farmed Atlantic salmon on plasma phospholipid fatty acid (PLFA) proportions and CVD risk biomarkers (glucose, insulin, HOMAIR, hsCRP, and IL-6) in healthy subjects we performed a randomized 3-period cross-over designed trial (4 wk treatment, 4-8 wk washout) to compare the effects of twice/wk consumption of farmed Atlantic salmon at doses of 90, 180, and 270 g in 19 apparently healthy men and women with a mean age of aged 40-65 years and a BMI between 25-34.9 kg/m2. All study visits were conducted at the USDA, ARS Grand Forks Human Nutrition Research Center. EPA and total n-3 were increased (p<0.05) by all treatments in a dose response manner, with total n-3 of 8.03 ± 0.26 and 9.21 ± 0.26 % for 180 and 270 g doses, respectively. Linoleic acid did not change in response to treatment while arachidonic acid (P<0.05) and total omega-6 fatty acids (n-6) decreased dose dependently (<0.0001). The addition of farmed Atlantic salmon to the diet twice/wk for 4 wk at portions of 180g and 270g modifies PLFA proportions of n-3 and n-6 in a level associated with decreased risk for CVD. Text Atlantic salmon Salmo salar PubMed Central (PMC) Grand Forks ENVELOPE(-139.317,-139.317,63.920,63.920) Journal of the Academy of Nutrition and Dietetics 113 2 282 287 |
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Article Raatz, Susan K. Rosenberger, Thad A. Johnson, LuAnn K. Wolters, William W. Burr, Gary S Picklo, Matthew J. Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
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Article |
description |
Enhanced omega-3 fatty acid (n-3) intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish intake on plasma levels of n-3 fatty acids. To compare the effects of different doses of farmed Atlantic salmon on plasma phospholipid fatty acid (PLFA) proportions and CVD risk biomarkers (glucose, insulin, HOMAIR, hsCRP, and IL-6) in healthy subjects we performed a randomized 3-period cross-over designed trial (4 wk treatment, 4-8 wk washout) to compare the effects of twice/wk consumption of farmed Atlantic salmon at doses of 90, 180, and 270 g in 19 apparently healthy men and women with a mean age of aged 40-65 years and a BMI between 25-34.9 kg/m2. All study visits were conducted at the USDA, ARS Grand Forks Human Nutrition Research Center. EPA and total n-3 were increased (p<0.05) by all treatments in a dose response manner, with total n-3 of 8.03 ± 0.26 and 9.21 ± 0.26 % for 180 and 270 g doses, respectively. Linoleic acid did not change in response to treatment while arachidonic acid (P<0.05) and total omega-6 fatty acids (n-6) decreased dose dependently (<0.0001). The addition of farmed Atlantic salmon to the diet twice/wk for 4 wk at portions of 180g and 270g modifies PLFA proportions of n-3 and n-6 in a level associated with decreased risk for CVD. |
format |
Text |
author |
Raatz, Susan K. Rosenberger, Thad A. Johnson, LuAnn K. Wolters, William W. Burr, Gary S Picklo, Matthew J. |
author_facet |
Raatz, Susan K. Rosenberger, Thad A. Johnson, LuAnn K. Wolters, William W. Burr, Gary S Picklo, Matthew J. |
author_sort |
Raatz, Susan K. |
title |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
title_short |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
title_full |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
title_fullStr |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
title_full_unstemmed |
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
title_sort |
dose-dependent consumption of farmed atlantic salmon (salmo salar) increases plasma phospholipid n-3 fatty acids differentially |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572904 http://www.ncbi.nlm.nih.gov/pubmed/23351633 https://doi.org/10.1016/j.jand.2012.09.022 |
long_lat |
ENVELOPE(-139.317,-139.317,63.920,63.920) |
geographic |
Grand Forks |
geographic_facet |
Grand Forks |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572904 http://www.ncbi.nlm.nih.gov/pubmed/23351633 http://dx.doi.org/10.1016/j.jand.2012.09.022 |
op_rights |
© 2012 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.jand.2012.09.022 |
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Journal of the Academy of Nutrition and Dietetics |
container_volume |
113 |
container_issue |
2 |
container_start_page |
282 |
op_container_end_page |
287 |
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1766360851674038272 |