Uric Acid, Hypertension, and CKD among Alaska Eskimos—the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study

• Published in: The Journal of Clinical Hypertension
• Main Authors: Jolly, Stacey E., Mete, Mihriye, Wang, Hong, Zhu, Jianhui, Ebbesson, Sven O.E., Voruganti, V. Saroja, Comuzzie, Anthony G., Howard, Barbara V., Umans, Jason G.
• Format: Text
• Language: English
• Published: 2012
• Subjects: Article; eskimo*; Alaska
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507473; http://www.ncbi.nlm.nih.gov/pubmed/22277138; https://doi.org/10.1111/j.1751-7176.2011.00574.x

It is unknown what role uric acid may play in the increasing cardiovascular disease (CVD) among Alaska Eskimos. Uric acid is associated with both hypertension (HTN) and chronic kidney disease (CKD). We analyzed 1078 Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) participants. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine measures using the MDRD equation. CKD was defined by an eGFR of <60ml/min/1.73m2. We adjusted for age, sex, education, diabetes, hypertension (or eGFR), obesity, lipids, and smoking status; 7% (n=75) had prevalent CKD. eGFR decreased with increasing tertiles of serum uric acid. (p<0.001) Uric acid was independently associated with prevalent CKD (Adjusted Odds Ratio [OR] and 95% confidence interval [CI] of 2.04 (1.62–2.56), respectively). 21% (n=230) had prevalent HTN; Uric acid was independently associated with prevalent HTN (Adjusted OR 1.2, 95% CI 1.1–1.5). Uric acid is independently associated with prevalent CKD and HTN in this population.