Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms
The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been imp...
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ftpubmed:oai:pubmedcentral.nih.gov:3503822 2023-05-15T16:17:07+02:00 Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms Larcombe, Linda Mookherjee, Neeloffer Slater, Joyce Slivinski, Caroline Singer, Matthew Whaley, Chris Denechezhe, Lizette Matyas, Sara Turner-Brannen, Emily Nickerson, Peter Orr, Pamela 2012-11-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503822 http://www.ncbi.nlm.nih.gov/pubmed/23185470 https://doi.org/10.1371/journal.pone.0049872 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503822 http://www.ncbi.nlm.nih.gov/pubmed/23185470 http://dx.doi.org/10.1371/journal.pone.0049872 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2012 ftpubmed https://doi.org/10.1371/journal.pone.0049872 2013-09-04T16:14:00Z The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases. The objectives of this study were to determine the contribution of vitamin D from food, and measure the serum concentrations of 25-hydroxyvitamin D3 (25-OHD3) and VDBP in Dené participants. Single nucleotide polymorphisms (SNPs) associated with the dysregulation of the innate immune response were typed and counted. Potential correlations between the SNPs and serum concentrations of 25-OHD3 and VDBP were evaluated. Venous blood was collected in summer and winter over a one-year period and analyzed for 25-OHD3 and VDBP concentrations (N = 46). A questionnaire was administered to determine the amount of dietary vitamin D consumed. Sixty-one percent and 30% of the participants had 25-OHD3 serum concentrations <75 nmol/L in the winter and summer respectively. Mean vitamin D binding protein concentrations were within the normal range in the winter but below normal in the summer. VDBP and VDR gene polymorphisms affect the bioavailability and regulation of 25-OHD3. The Dené had a high frequency of the VDBP D432E-G allele (71%) and the Gc1 genotype (90%), associated with high concentrations of VDBP and a high binding affinity to 25-OHD3. The Dené had a high frequency of VDR Fok1-f allele (82%), which has been associated with a down-regulated Th1 immune response. VDBP and VDR polymorphisms, and low winter 25-OHD3 serum concentrations may be risk factors for infectious diseases and chronic conditions related to the dysregulation of the vitamin D pathway. Text First Nations PubMed Central (PMC) PLoS ONE 7 11 e49872 |
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Research Article Larcombe, Linda Mookherjee, Neeloffer Slater, Joyce Slivinski, Caroline Singer, Matthew Whaley, Chris Denechezhe, Lizette Matyas, Sara Turner-Brannen, Emily Nickerson, Peter Orr, Pamela Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
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Research Article |
description |
The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases. The objectives of this study were to determine the contribution of vitamin D from food, and measure the serum concentrations of 25-hydroxyvitamin D3 (25-OHD3) and VDBP in Dené participants. Single nucleotide polymorphisms (SNPs) associated with the dysregulation of the innate immune response were typed and counted. Potential correlations between the SNPs and serum concentrations of 25-OHD3 and VDBP were evaluated. Venous blood was collected in summer and winter over a one-year period and analyzed for 25-OHD3 and VDBP concentrations (N = 46). A questionnaire was administered to determine the amount of dietary vitamin D consumed. Sixty-one percent and 30% of the participants had 25-OHD3 serum concentrations <75 nmol/L in the winter and summer respectively. Mean vitamin D binding protein concentrations were within the normal range in the winter but below normal in the summer. VDBP and VDR gene polymorphisms affect the bioavailability and regulation of 25-OHD3. The Dené had a high frequency of the VDBP D432E-G allele (71%) and the Gc1 genotype (90%), associated with high concentrations of VDBP and a high binding affinity to 25-OHD3. The Dené had a high frequency of VDR Fok1-f allele (82%), which has been associated with a down-regulated Th1 immune response. VDBP and VDR polymorphisms, and low winter 25-OHD3 serum concentrations may be risk factors for infectious diseases and chronic conditions related to the dysregulation of the vitamin D pathway. |
format |
Text |
author |
Larcombe, Linda Mookherjee, Neeloffer Slater, Joyce Slivinski, Caroline Singer, Matthew Whaley, Chris Denechezhe, Lizette Matyas, Sara Turner-Brannen, Emily Nickerson, Peter Orr, Pamela |
author_facet |
Larcombe, Linda Mookherjee, Neeloffer Slater, Joyce Slivinski, Caroline Singer, Matthew Whaley, Chris Denechezhe, Lizette Matyas, Sara Turner-Brannen, Emily Nickerson, Peter Orr, Pamela |
author_sort |
Larcombe, Linda |
title |
Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
title_short |
Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
title_full |
Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
title_fullStr |
Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
title_full_unstemmed |
Vitamin D in a Northern Canadian First Nation Population: Dietary Intake, Serum Concentrations and Functional Gene Polymorphisms |
title_sort |
vitamin d in a northern canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms |
publisher |
Public Library of Science |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503822 http://www.ncbi.nlm.nih.gov/pubmed/23185470 https://doi.org/10.1371/journal.pone.0049872 |
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First Nations |
genre_facet |
First Nations |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503822 http://www.ncbi.nlm.nih.gov/pubmed/23185470 http://dx.doi.org/10.1371/journal.pone.0049872 |
op_rights |
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0049872 |
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PLoS ONE |
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7 |
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11 |
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e49872 |
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1766002963819528192 |