Massive Colchicine Overdose with Recovery
Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ fail...
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ftpubmed:oai:pubmedcentral.nih.gov:3482071 2023-05-15T16:16:31+02:00 Massive Colchicine Overdose with Recovery Iosfina, Ioulia Lan, James Chin, Carson Werb, Ronald Levin, Adeera 2012-04-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482071 http://www.ncbi.nlm.nih.gov/pubmed/23197951 https://doi.org/10.1159/000338269 en eng S. Karger AG http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482071 http://www.ncbi.nlm.nih.gov/pubmed/23197951 http://dx.doi.org/10.1159/000338269 Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. CC-BY-NC-ND Published: April 2012 Text 2012 ftpubmed https://doi.org/10.1159/000338269 2013-09-04T15:02:13Z Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ failure, whether directly from colchicine toxicity or due to ensuing sepsis. We report an extreme case of colchicine ingestion (1.38 mg/kg), which is the largest reported non-fatal colchicine overdose. The patient was a 47-year-old First Nations woman with a history of depression and no other comorbidities. Ingestion was intentional and initial presentation was within 2 h of ingestion, at which point she had normal clinical and laboratory parameters. Early implementation of a targeted therapeutic strategy directed at the predicted multi-organ failure which included aggressive use of a GI decontamination protocol, timely supportive measures including ventilator support and renal replacement therapy, as well as the utilization of broad-spectrum antibiotics and G-CSF for sepsis and leucopenia management, resulted in successful support and discharge of this patient off dialysis. Text First Nations PubMed Central (PMC) Case Reports in Nephrology and Urology 2 1 20 24 |
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Published: April 2012 Iosfina, Ioulia Lan, James Chin, Carson Werb, Ronald Levin, Adeera Massive Colchicine Overdose with Recovery |
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Published: April 2012 |
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Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ failure, whether directly from colchicine toxicity or due to ensuing sepsis. We report an extreme case of colchicine ingestion (1.38 mg/kg), which is the largest reported non-fatal colchicine overdose. The patient was a 47-year-old First Nations woman with a history of depression and no other comorbidities. Ingestion was intentional and initial presentation was within 2 h of ingestion, at which point she had normal clinical and laboratory parameters. Early implementation of a targeted therapeutic strategy directed at the predicted multi-organ failure which included aggressive use of a GI decontamination protocol, timely supportive measures including ventilator support and renal replacement therapy, as well as the utilization of broad-spectrum antibiotics and G-CSF for sepsis and leucopenia management, resulted in successful support and discharge of this patient off dialysis. |
format |
Text |
author |
Iosfina, Ioulia Lan, James Chin, Carson Werb, Ronald Levin, Adeera |
author_facet |
Iosfina, Ioulia Lan, James Chin, Carson Werb, Ronald Levin, Adeera |
author_sort |
Iosfina, Ioulia |
title |
Massive Colchicine Overdose with Recovery |
title_short |
Massive Colchicine Overdose with Recovery |
title_full |
Massive Colchicine Overdose with Recovery |
title_fullStr |
Massive Colchicine Overdose with Recovery |
title_full_unstemmed |
Massive Colchicine Overdose with Recovery |
title_sort |
massive colchicine overdose with recovery |
publisher |
S. Karger AG |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482071 http://www.ncbi.nlm.nih.gov/pubmed/23197951 https://doi.org/10.1159/000338269 |
genre |
First Nations |
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First Nations |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482071 http://www.ncbi.nlm.nih.gov/pubmed/23197951 http://dx.doi.org/10.1159/000338269 |
op_rights |
Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1159/000338269 |
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Case Reports in Nephrology and Urology |
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2 |
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1 |
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20 |
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24 |
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1766002380895158272 |