Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years
Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark,...
Published in: | Journal of Clinical Microbiology |
---|---|
Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
American Society for Microbiology
2012
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421533 http://www.ncbi.nlm.nih.gov/pubmed/22675129 https://doi.org/10.1128/JCM.06358-11 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:3421533 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:3421533 2023-05-15T16:30:58+02:00 Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years Kamper-Jørgensen, Z. Andersen, A. B. Kok-Jensen, A. Bygbjerg, I. C. Andersen, P. H. Thomsen, V. O. Kamper-Jørgensen, M. Lillebaek, T. 2012-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421533 http://www.ncbi.nlm.nih.gov/pubmed/22675129 https://doi.org/10.1128/JCM.06358-11 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421533 http://www.ncbi.nlm.nih.gov/pubmed/22675129 http://dx.doi.org/10.1128/JCM.06358-11 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Epidemiology Text 2012 ftpubmed https://doi.org/10.1128/JCM.06358-11 2013-09-04T11:39:12Z Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (≥50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 enviornment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation. Text greenlander* PubMed Central (PMC) Journal of Clinical Microbiology 50 8 2660 2667 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Epidemiology |
spellingShingle |
Epidemiology Kamper-Jørgensen, Z. Andersen, A. B. Kok-Jensen, A. Bygbjerg, I. C. Andersen, P. H. Thomsen, V. O. Kamper-Jørgensen, M. Lillebaek, T. Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
topic_facet |
Epidemiology |
description |
Molecular genotyping of Mycobacterium tuberculosis has proved to be a powerful tool in tuberculosis surveillance, epidemiology, and control. Based on results obtained through 15 years of nationwide IS6110 restriction fragment length polymorphism (RFLP) genotyping of M. tuberculosis cases in Denmark, a country on the way toward tuberculosis elimination, we discuss M. tuberculosis transmission dynamics and point to areas for control interventions. Cases with 100% identical genotypes (RFLP patterns) were defined as clustered, and a cluster was defined as cases with an identical genotype. Of 4,601 included cases, corresponding to 76% of reported and 97% of culture-verified tuberculosis cases in the country, 56% were clustered, of which 69% were Danes. Generally, Danes were more often in large clusters (≥50 persons), older (mean age, 45 years), and male (male/female ratio, 2.5). Also, Danes had a higher cluster frequency within a 2-year observation window (60.8%), and higher clustering rate of new patterns over time, compared to immigrants. A dominant genotype, cluster 2, constituted 44% of all clustered and 35% of all genotyped cases. This cluster was primarily found among Danish males, 30 to 59 years of age, often socially marginalized, and with records of alcohol abuse. In Danes, cluster 2 alone was responsible for the high cluster frequency level. Immigrants had a higher incidence of clustered tuberculosis at a younger age (0 to 39 years). To achieve tuberculosis elimination in Denmark, high-risk transmission environments, like the cluster 2 enviornment in Danes, and specific transmission chains in immigrants in the capital area, e.g., homeless/socially marginalized Somalis/Greenlanders, often with alcohol abuse, must be targeted, including groups with a high risk of reactivation. |
format |
Text |
author |
Kamper-Jørgensen, Z. Andersen, A. B. Kok-Jensen, A. Bygbjerg, I. C. Andersen, P. H. Thomsen, V. O. Kamper-Jørgensen, M. Lillebaek, T. |
author_facet |
Kamper-Jørgensen, Z. Andersen, A. B. Kok-Jensen, A. Bygbjerg, I. C. Andersen, P. H. Thomsen, V. O. Kamper-Jørgensen, M. Lillebaek, T. |
author_sort |
Kamper-Jørgensen, Z. |
title |
Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
title_short |
Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
title_full |
Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
title_fullStr |
Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
title_full_unstemmed |
Clustered Tuberculosis in a Low-Burden Country: Nationwide Genotyping through 15 Years |
title_sort |
clustered tuberculosis in a low-burden country: nationwide genotyping through 15 years |
publisher |
American Society for Microbiology |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421533 http://www.ncbi.nlm.nih.gov/pubmed/22675129 https://doi.org/10.1128/JCM.06358-11 |
genre |
greenlander* |
genre_facet |
greenlander* |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421533 http://www.ncbi.nlm.nih.gov/pubmed/22675129 http://dx.doi.org/10.1128/JCM.06358-11 |
op_rights |
Copyright © 2012, American Society for Microbiology. All Rights Reserved. |
op_doi |
https://doi.org/10.1128/JCM.06358-11 |
container_title |
Journal of Clinical Microbiology |
container_volume |
50 |
container_issue |
8 |
container_start_page |
2660 |
op_container_end_page |
2667 |
_version_ |
1766020782312390656 |