The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec
The aim of this study was to investigate the association between prenatal exposure to lead (Pb) and several aspects of behavioral function during infancy through examiner ratings and behavioral coding of video recordings. The sample consisted of 169 11-month old Inuit infants from Arctic Quebec. Umb...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417247 http://www.ncbi.nlm.nih.gov/pubmed/17706923 https://doi.org/10.1016/j.ntt.2007.07.002 |
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ftpubmed:oai:pubmedcentral.nih.gov:3417247 2023-05-15T14:57:13+02:00 The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec Plusquellec, P. Muckle, G. Dewailly, E. Ayotte, P. Jacobson, S.W. Jacobson, J.L. 2007-08-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417247 http://www.ncbi.nlm.nih.gov/pubmed/17706923 https://doi.org/10.1016/j.ntt.2007.07.002 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417247 http://www.ncbi.nlm.nih.gov/pubmed/17706923 http://dx.doi.org/10.1016/j.ntt.2007.07.002 Article Text 2007 ftpubmed https://doi.org/10.1016/j.ntt.2007.07.002 2013-09-04T11:23:12Z The aim of this study was to investigate the association between prenatal exposure to lead (Pb) and several aspects of behavioral function during infancy through examiner ratings and behavioral coding of video recordings. The sample consisted of 169 11-month old Inuit infants from Arctic Quebec. Umbilical cord and maternal blood samples were used to document prenatal exposure to Pb. Average blood Pb levels were 4.6 μg/dL and 5.9 μg/dL in cord and maternal samples respectively. The Behavior Rating Scales (BRS) from the Bayley Scales of Infant Development (BSID-II) were used to assess behavior. Attention was assessed through the BRS and behavioral coding of video recordings taken during the administration of the BSID-II. Whereas the examiner ratings of behaviors detected very few associations with prenatal Pb exposure, cord blood Pb concentrations were significantly related to the direct observational measures of infant attention, after adjustment for confounding variables. These data provide evidence that increasing the specificity and the precision of the behavioral assessment has considerable potential for improving our ability to detect low-to-moderate associations between neurotoxicants, such Pb and infant behavior. Text Arctic inuit PubMed Central (PMC) Arctic Neurotoxicology and Teratology 29 5 527 537 |
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Article Plusquellec, P. Muckle, G. Dewailly, E. Ayotte, P. Jacobson, S.W. Jacobson, J.L. The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
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The aim of this study was to investigate the association between prenatal exposure to lead (Pb) and several aspects of behavioral function during infancy through examiner ratings and behavioral coding of video recordings. The sample consisted of 169 11-month old Inuit infants from Arctic Quebec. Umbilical cord and maternal blood samples were used to document prenatal exposure to Pb. Average blood Pb levels were 4.6 μg/dL and 5.9 μg/dL in cord and maternal samples respectively. The Behavior Rating Scales (BRS) from the Bayley Scales of Infant Development (BSID-II) were used to assess behavior. Attention was assessed through the BRS and behavioral coding of video recordings taken during the administration of the BSID-II. Whereas the examiner ratings of behaviors detected very few associations with prenatal Pb exposure, cord blood Pb concentrations were significantly related to the direct observational measures of infant attention, after adjustment for confounding variables. These data provide evidence that increasing the specificity and the precision of the behavioral assessment has considerable potential for improving our ability to detect low-to-moderate associations between neurotoxicants, such Pb and infant behavior. |
format |
Text |
author |
Plusquellec, P. Muckle, G. Dewailly, E. Ayotte, P. Jacobson, S.W. Jacobson, J.L. |
author_facet |
Plusquellec, P. Muckle, G. Dewailly, E. Ayotte, P. Jacobson, S.W. Jacobson, J.L. |
author_sort |
Plusquellec, P. |
title |
The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
title_short |
The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
title_full |
The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
title_fullStr |
The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
title_full_unstemmed |
The Relation of Low-level Prenatal Lead Exposure to Behavioral Indicators of Attention in Inuit Infants in Arctic Quebec |
title_sort |
relation of low-level prenatal lead exposure to behavioral indicators of attention in inuit infants in arctic quebec |
publishDate |
2007 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417247 http://www.ncbi.nlm.nih.gov/pubmed/17706923 https://doi.org/10.1016/j.ntt.2007.07.002 |
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Arctic |
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Arctic |
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Arctic inuit |
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Arctic inuit |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417247 http://www.ncbi.nlm.nih.gov/pubmed/17706923 http://dx.doi.org/10.1016/j.ntt.2007.07.002 |
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https://doi.org/10.1016/j.ntt.2007.07.002 |
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Neurotoxicology and Teratology |
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29 |
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5 |
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527 |
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537 |
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1766329311182192640 |