Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia
The prion protein (PrP) sequence of European moose, reindeer, roe deer and fallow deer in Scandinavia has high homology to the PrP sequence of North American cervids. Variants in the European moose PrP sequence were found at amino acid position 109 as K or Q. The 109Q variant is unique in the PrP se...
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Landes Bioscience
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ftpubmed:oai:pubmedcentral.nih.gov:3399539 2023-05-15T13:13:16+02:00 Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia Wik, Lotta Mikko, Sofia Klingeborn, Mikael Stéen, Margareta Simonsson, Magnus Linné, Tommy 2012-07-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399539 http://www.ncbi.nlm.nih.gov/pubmed/22441661 https://doi.org/10.4161/pri.19641 en eng Landes Bioscience http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399539 http://www.ncbi.nlm.nih.gov/pubmed/22441661 http://dx.doi.org/10.4161/pri.19641 Copyright © 2012 Landes Bioscience Short Communication Text 2012 ftpubmed https://doi.org/10.4161/pri.19641 2013-09-04T10:16:07Z The prion protein (PrP) sequence of European moose, reindeer, roe deer and fallow deer in Scandinavia has high homology to the PrP sequence of North American cervids. Variants in the European moose PrP sequence were found at amino acid position 109 as K or Q. The 109Q variant is unique in the PrP sequence of vertebrates. During the 1980s a wasting syndrome in Swedish moose, Moose Wasting Syndrome (MWS), was described. SNP analysis demonstrated a difference in the observed genotype proportions of the heterozygous Q/K and homozygous Q/Q variants in the MWS animals compared with the healthy animals. In MWS moose the allele frequencies for 109K and 109Q were 0.73 and 0.27, respectively, and for healthy animals 0.69 and 0.31. Both alleles were seen as heterozygotes and homozygotes. In reindeer, PrP sequence variation was demonstrated at codon 176 as D or N and codon 225 as S or Y. The PrP sequences in roe deer and fallow deer were identical with published GenBank sequences. Text Alces alces Rangifer tarandus PubMed Central (PMC) Prion 6 3 256 260 |
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Short Communication |
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Short Communication Wik, Lotta Mikko, Sofia Klingeborn, Mikael Stéen, Margareta Simonsson, Magnus Linné, Tommy Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
topic_facet |
Short Communication |
description |
The prion protein (PrP) sequence of European moose, reindeer, roe deer and fallow deer in Scandinavia has high homology to the PrP sequence of North American cervids. Variants in the European moose PrP sequence were found at amino acid position 109 as K or Q. The 109Q variant is unique in the PrP sequence of vertebrates. During the 1980s a wasting syndrome in Swedish moose, Moose Wasting Syndrome (MWS), was described. SNP analysis demonstrated a difference in the observed genotype proportions of the heterozygous Q/K and homozygous Q/Q variants in the MWS animals compared with the healthy animals. In MWS moose the allele frequencies for 109K and 109Q were 0.73 and 0.27, respectively, and for healthy animals 0.69 and 0.31. Both alleles were seen as heterozygotes and homozygotes. In reindeer, PrP sequence variation was demonstrated at codon 176 as D or N and codon 225 as S or Y. The PrP sequences in roe deer and fallow deer were identical with published GenBank sequences. |
format |
Text |
author |
Wik, Lotta Mikko, Sofia Klingeborn, Mikael Stéen, Margareta Simonsson, Magnus Linné, Tommy |
author_facet |
Wik, Lotta Mikko, Sofia Klingeborn, Mikael Stéen, Margareta Simonsson, Magnus Linné, Tommy |
author_sort |
Wik, Lotta |
title |
Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
title_short |
Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
title_full |
Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
title_fullStr |
Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
title_full_unstemmed |
Polymorphisms and variants in the prion protein sequence of European moose (Alces alces), reindeer (Rangifer tarandus), roe deer (Capreolus capreolus) and fallow deer (Dama dama) in Scandinavia |
title_sort |
polymorphisms and variants in the prion protein sequence of european moose (alces alces), reindeer (rangifer tarandus), roe deer (capreolus capreolus) and fallow deer (dama dama) in scandinavia |
publisher |
Landes Bioscience |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399539 http://www.ncbi.nlm.nih.gov/pubmed/22441661 https://doi.org/10.4161/pri.19641 |
genre |
Alces alces Rangifer tarandus |
genre_facet |
Alces alces Rangifer tarandus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399539 http://www.ncbi.nlm.nih.gov/pubmed/22441661 http://dx.doi.org/10.4161/pri.19641 |
op_rights |
Copyright © 2012 Landes Bioscience |
op_doi |
https://doi.org/10.4161/pri.19641 |
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