Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears
The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complex mixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 East Greenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) was analyz...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366032 http://www.ncbi.nlm.nih.gov/pubmed/22575327 https://doi.org/10.1016/j.envres.2012.04.010 |
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ftpubmed:oai:pubmedcentral.nih.gov:3366032 2023-05-15T16:03:31+02:00 Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears TØ, Bechshøft Sonne, C Dietz, R Born, EW Muir, DCG Letcher, RJ Novak, MA Henchey, E Meyer, JS Jenssen, BM Villanger, GD 2012-05-08 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366032 http://www.ncbi.nlm.nih.gov/pubmed/22575327 https://doi.org/10.1016/j.envres.2012.04.010 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366032 http://www.ncbi.nlm.nih.gov/pubmed/22575327 http://dx.doi.org/10.1016/j.envres.2012.04.010 © 2012 Elsevier Inc. All rights reserved. Article Text 2012 ftpubmed https://doi.org/10.1016/j.envres.2012.04.010 2013-09-04T08:08:35Z The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complex mixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 East Greenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) was analyzed using projection to latent structure (PLS) regression modeling. In the resulting PLS model, most important variables with a negative influence on cortisol levels were particularly BDE-99, but also CB-180, -201, BDE-153, and CB-170/190. The most important variables with a positive influence on cortisol were CB-66/95, α-HCH, TT3, as well as heptachlor epoxide, dieldrin, BDE-47, p,p′-DDD. Although statistical modeling does not necessarily fully explain biological cause-effect relationships, relationships indicate that (1) the hypothalamic-pituitary-adrenal (HPA) axis in East Greenland polar bears is likely to be affected by OHC-contaminants and (2) the association between OHCs and cortisol may be linked with the hypothalamus-pituitary-thyroid (HPT) axis. Text East Greenland Greenland PubMed Central (PMC) Greenland Environmental Research 116 26 35 |
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Article TØ, Bechshøft Sonne, C Dietz, R Born, EW Muir, DCG Letcher, RJ Novak, MA Henchey, E Meyer, JS Jenssen, BM Villanger, GD Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
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description |
The multivariate relationship between hair cortisol, whole blood thyroid hormones, and the complex mixtures of organohalogen contaminant (OHC) levels measured in subcutaneous adipose of 23 East Greenland polar bears (eight males and 15 females, all sampled between the years 1999 and 2001) was analyzed using projection to latent structure (PLS) regression modeling. In the resulting PLS model, most important variables with a negative influence on cortisol levels were particularly BDE-99, but also CB-180, -201, BDE-153, and CB-170/190. The most important variables with a positive influence on cortisol were CB-66/95, α-HCH, TT3, as well as heptachlor epoxide, dieldrin, BDE-47, p,p′-DDD. Although statistical modeling does not necessarily fully explain biological cause-effect relationships, relationships indicate that (1) the hypothalamic-pituitary-adrenal (HPA) axis in East Greenland polar bears is likely to be affected by OHC-contaminants and (2) the association between OHCs and cortisol may be linked with the hypothalamus-pituitary-thyroid (HPT) axis. |
format |
Text |
author |
TØ, Bechshøft Sonne, C Dietz, R Born, EW Muir, DCG Letcher, RJ Novak, MA Henchey, E Meyer, JS Jenssen, BM Villanger, GD |
author_facet |
TØ, Bechshøft Sonne, C Dietz, R Born, EW Muir, DCG Letcher, RJ Novak, MA Henchey, E Meyer, JS Jenssen, BM Villanger, GD |
author_sort |
TØ, Bechshøft |
title |
Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
title_short |
Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
title_full |
Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
title_fullStr |
Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
title_full_unstemmed |
Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears |
title_sort |
associations between complex ohc mixtures and thyroid and cortisol hormone levels in east greenland polar bears |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366032 http://www.ncbi.nlm.nih.gov/pubmed/22575327 https://doi.org/10.1016/j.envres.2012.04.010 |
geographic |
Greenland |
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Greenland |
genre |
East Greenland Greenland |
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East Greenland Greenland |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366032 http://www.ncbi.nlm.nih.gov/pubmed/22575327 http://dx.doi.org/10.1016/j.envres.2012.04.010 |
op_rights |
© 2012 Elsevier Inc. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.envres.2012.04.010 |
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Environmental Research |
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116 |
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26 |
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35 |
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1766399192699240448 |