Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002
This study measured organochlorine pesticides (OCPs) including hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), heptachlor and dichlorodiphenyltrichloroethanes (DDTs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polybrominated diphenyl ethers (PBDEs) in tissues o...
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ftpubmed:oai:pubmedcentral.nih.gov:3361608 2023-05-15T17:58:57+02:00 Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 Wang, Dongli Atkinson, Shannon Hoover-Miller, Anne Shelver, Weilin L. Li, Qing X. 2012-04-28 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361608 http://www.ncbi.nlm.nih.gov/pubmed/22579763 https://doi.org/10.1016/j.jhazmat.2012.04.052 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361608 http://www.ncbi.nlm.nih.gov/pubmed/22579763 http://dx.doi.org/10.1016/j.jhazmat.2012.04.052 © 2012 Elsevier B.V. All rights reserved. Article Text 2012 ftpubmed https://doi.org/10.1016/j.jhazmat.2012.04.052 2013-09-04T07:51:11Z This study measured organochlorine pesticides (OCPs) including hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), heptachlor and dichlorodiphenyltrichloroethanes (DDTs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polybrominated diphenyl ethers (PBDEs) in tissues of six mother–fetus pairs of harbor seals that were hunted for subsistence in Alaska waters of the Northern Pacific Ocean. These data suggest that significant amounts of these contaminants were transferred from mother harbor seals to fetuses during pregnancy and distributed among fetal organs. The tissue distribution depended on the chemical groups, the specific compounds in the groups and the target organs. Concentration profiles of ΣOCPs, ΣPCBs, ΣPCNs and ΣPBDEs were remarkably similar among maternal blubber, liver, and placenta, fetal blubber, and liver (except for HCHs), possibly indicating that the placenta did not serve as a barrier for all of the compounds analyzed. DDTs, HCB, HCHs, PCBs and PBDEs could penetrate the placenta and accumulate in the blubber of the fetus in utero, while HCHs, PCBs and PBDEs penetrated the placenta and accumulated more preferentially in the fetal liver than in the fetal brain in comparison with DDTs and HCB. Heptachlor and PCNs penetrated the placenta and accumulated in the fetal liver and brain instead of fetal blubber. Similar maternal transfer trends for OCPs, PCBs, PCNs and PBDEs were shown by fetal to maternal (FM) blubber ratios and FM liver ratios. Prenatal transfer of these toxic contaminants from mothers to fetus presumably through the placenta may pose health risks to the fetus during development. Text Phoca vitulina Alaska PubMed Central (PMC) Pacific Journal of Hazardous Materials 223-224 72 78 |
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Article Wang, Dongli Atkinson, Shannon Hoover-Miller, Anne Shelver, Weilin L. Li, Qing X. Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
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Article |
description |
This study measured organochlorine pesticides (OCPs) including hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), heptachlor and dichlorodiphenyltrichloroethanes (DDTs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polybrominated diphenyl ethers (PBDEs) in tissues of six mother–fetus pairs of harbor seals that were hunted for subsistence in Alaska waters of the Northern Pacific Ocean. These data suggest that significant amounts of these contaminants were transferred from mother harbor seals to fetuses during pregnancy and distributed among fetal organs. The tissue distribution depended on the chemical groups, the specific compounds in the groups and the target organs. Concentration profiles of ΣOCPs, ΣPCBs, ΣPCNs and ΣPBDEs were remarkably similar among maternal blubber, liver, and placenta, fetal blubber, and liver (except for HCHs), possibly indicating that the placenta did not serve as a barrier for all of the compounds analyzed. DDTs, HCB, HCHs, PCBs and PBDEs could penetrate the placenta and accumulate in the blubber of the fetus in utero, while HCHs, PCBs and PBDEs penetrated the placenta and accumulated more preferentially in the fetal liver than in the fetal brain in comparison with DDTs and HCB. Heptachlor and PCNs penetrated the placenta and accumulated in the fetal liver and brain instead of fetal blubber. Similar maternal transfer trends for OCPs, PCBs, PCNs and PBDEs were shown by fetal to maternal (FM) blubber ratios and FM liver ratios. Prenatal transfer of these toxic contaminants from mothers to fetus presumably through the placenta may pose health risks to the fetus during development. |
format |
Text |
author |
Wang, Dongli Atkinson, Shannon Hoover-Miller, Anne Shelver, Weilin L. Li, Qing X. |
author_facet |
Wang, Dongli Atkinson, Shannon Hoover-Miller, Anne Shelver, Weilin L. Li, Qing X. |
author_sort |
Wang, Dongli |
title |
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
title_short |
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
title_full |
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
title_fullStr |
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
title_full_unstemmed |
Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000–2002 |
title_sort |
organic halogenated contaminants in mother-fetus pairs of harbor seals (phoca vitulina richardii) from alaska, 2000–2002 |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361608 http://www.ncbi.nlm.nih.gov/pubmed/22579763 https://doi.org/10.1016/j.jhazmat.2012.04.052 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Phoca vitulina Alaska |
genre_facet |
Phoca vitulina Alaska |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361608 http://www.ncbi.nlm.nih.gov/pubmed/22579763 http://dx.doi.org/10.1016/j.jhazmat.2012.04.052 |
op_rights |
© 2012 Elsevier B.V. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.jhazmat.2012.04.052 |
container_title |
Journal of Hazardous Materials |
container_volume |
223-224 |
container_start_page |
72 |
op_container_end_page |
78 |
_version_ |
1766167673491685376 |