Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs
Dietary habits that expose populations to potential toxicants as well as protective agents simultaneously is a realistic scenario where a meaningful assessment of the interactions and net benefit or damage can be made. A group of Inuit from Salluit, Northern Canada are exposed to high levels of PCBs...
Published in: | Environment International |
---|---|
Main Authors: | , , , , , |
Format: | Text |
Language: | English |
Published: |
2009
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354714 http://www.ncbi.nlm.nih.gov/pubmed/19735942 https://doi.org/10.1016/j.envint.2009.08.001 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:3354714 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:3354714 2023-05-15T16:54:49+02:00 Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs Ravoori, Srivani Srinivasan, Cidambi Pereg, Daria Robertson, Larry W Ayotte, Pierre Gupta, Ramesh C 2009-09-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354714 http://www.ncbi.nlm.nih.gov/pubmed/19735942 https://doi.org/10.1016/j.envint.2009.08.001 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354714 http://www.ncbi.nlm.nih.gov/pubmed/19735942 http://dx.doi.org/10.1016/j.envint.2009.08.001 © 2009 Elsevier Ltd. All rights reserved. Article Text 2009 ftpubmed https://doi.org/10.1016/j.envint.2009.08.001 2013-09-04T07:24:10Z Dietary habits that expose populations to potential toxicants as well as protective agents simultaneously is a realistic scenario where a meaningful assessment of the interactions and net benefit or damage can be made. A group of Inuit from Salluit, Northern Canada are exposed to high levels of PCBs and selenium, both present in the Inuit traditional foods such as blubber from sea mammals and fatty fish. Blood samples were collected from 83 Inuit, 22–70 years old. Blood selenium and PCB levels were determined previously and ranged from 227 to 2,069 µg/L and 1.7 to 143 µg/L, respectively. DNA isolated from white blood cells were analyzed by modified 32P-postlabeling adductomics technology that detects a multitude of highly polar to lipophilic adducts. The levels of 8-oxodG adducts ranged from 470 to 7,400 adducts/109 nucleotides. Other as yet unidentified polar adducts showed a 30 to 800–fold inter-individual variability. Adduct levels were negatively associated with PCB and selenium levels. The subjects were classified into high and low ratio groups, with respect to selenium/PCB. In the high ratio group, the coefficient of selenium is significantly negatively correlated with 8-oxodG (r = −0.38, p = 0.014) and total adducts (r = −0.41, p = 0.009) while there was no correlation within the low selenium/PCB group. This study suggests increasing selenium has mitigating effect in reducing DNA adducts and therefore, possible negative effects of PCB were not rendered. A protective effect of selenium is highlighted. Text inuit Salluit PubMed Central (PMC) Canada Salluit ENVELOPE(-75.643,-75.643,62.204,62.204) Environment International 36 8 980 986 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Ravoori, Srivani Srinivasan, Cidambi Pereg, Daria Robertson, Larry W Ayotte, Pierre Gupta, Ramesh C Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
topic_facet |
Article |
description |
Dietary habits that expose populations to potential toxicants as well as protective agents simultaneously is a realistic scenario where a meaningful assessment of the interactions and net benefit or damage can be made. A group of Inuit from Salluit, Northern Canada are exposed to high levels of PCBs and selenium, both present in the Inuit traditional foods such as blubber from sea mammals and fatty fish. Blood samples were collected from 83 Inuit, 22–70 years old. Blood selenium and PCB levels were determined previously and ranged from 227 to 2,069 µg/L and 1.7 to 143 µg/L, respectively. DNA isolated from white blood cells were analyzed by modified 32P-postlabeling adductomics technology that detects a multitude of highly polar to lipophilic adducts. The levels of 8-oxodG adducts ranged from 470 to 7,400 adducts/109 nucleotides. Other as yet unidentified polar adducts showed a 30 to 800–fold inter-individual variability. Adduct levels were negatively associated with PCB and selenium levels. The subjects were classified into high and low ratio groups, with respect to selenium/PCB. In the high ratio group, the coefficient of selenium is significantly negatively correlated with 8-oxodG (r = −0.38, p = 0.014) and total adducts (r = −0.41, p = 0.009) while there was no correlation within the low selenium/PCB group. This study suggests increasing selenium has mitigating effect in reducing DNA adducts and therefore, possible negative effects of PCB were not rendered. A protective effect of selenium is highlighted. |
format |
Text |
author |
Ravoori, Srivani Srinivasan, Cidambi Pereg, Daria Robertson, Larry W Ayotte, Pierre Gupta, Ramesh C |
author_facet |
Ravoori, Srivani Srinivasan, Cidambi Pereg, Daria Robertson, Larry W Ayotte, Pierre Gupta, Ramesh C |
author_sort |
Ravoori, Srivani |
title |
Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
title_short |
Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
title_full |
Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
title_fullStr |
Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
title_full_unstemmed |
Protective effects of selenium against DNA adducts formation in Inuit environmentally exposed to PCBs |
title_sort |
protective effects of selenium against dna adducts formation in inuit environmentally exposed to pcbs |
publishDate |
2009 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354714 http://www.ncbi.nlm.nih.gov/pubmed/19735942 https://doi.org/10.1016/j.envint.2009.08.001 |
long_lat |
ENVELOPE(-75.643,-75.643,62.204,62.204) |
geographic |
Canada Salluit |
geographic_facet |
Canada Salluit |
genre |
inuit Salluit |
genre_facet |
inuit Salluit |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354714 http://www.ncbi.nlm.nih.gov/pubmed/19735942 http://dx.doi.org/10.1016/j.envint.2009.08.001 |
op_rights |
© 2009 Elsevier Ltd. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.envint.2009.08.001 |
container_title |
Environment International |
container_volume |
36 |
container_issue |
8 |
container_start_page |
980 |
op_container_end_page |
986 |
_version_ |
1766045656793743360 |