Neisseria meningitidis Sequence Type and Risk for Death, Iceland
Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and...
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ftpubmed:oai:pubmedcentral.nih.gov:3291058 2023-05-15T16:45:58+02:00 Neisseria meningitidis Sequence Type and Risk for Death, Iceland Gottfreðsson, Magnús Diggle, Mathew A. Lawrie, David I. Erlendsdóttir, Helga Harðardóttir, Hjördís Kristinsson, Karl G. Clarke, Stuart C. 2006-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291058 http://www.ncbi.nlm.nih.gov/pubmed/16836822 https://doi.org/10.3201/eid1207.051624 en eng Centers for Disease Control and Prevention http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291058 http://www.ncbi.nlm.nih.gov/pubmed/16836822 http://dx.doi.org/10.3201/eid1207.051624 Research Text 2006 ftpubmed https://doi.org/10.3201/eid1207.051624 2013-09-04T03:22:27Z Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p<0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome. Text Iceland PubMed Central (PMC) Emerging Infectious Diseases 12 7 1066 1073 |
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Research Gottfreðsson, Magnús Diggle, Mathew A. Lawrie, David I. Erlendsdóttir, Helga Harðardóttir, Hjördís Kristinsson, Karl G. Clarke, Stuart C. Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
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Research |
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Invasive meningococcal infections are hyperendemic in Iceland, a relatively isolated country in the mid-Atlantic. We performed a nationwide study on all viable meningococcal strains (N = 362) from 1977 to 2004. We analyzed the association of patient's age and sex, meningococcal serogroups, and sequence types (STs) with outcomes. Overall, 59 different STs were identified, 19 of which were unique to Iceland. The most common STs were 32 (24.6%), 11 (19.9%), and 10 (10.2%). The unique ST-3492 ranked fourth (7.7%). The most common serogroups were B (56.4%), C (39.8%), and A (2.2%). Age (p<0.001) and infection with a unique ST (p = 0.011) were independently associated with increased death rates, whereas isolation of meningococci from cerebrospinal fluid only was associated with lower death rates (p = 0.046). This study shows evolutionary trends of meningococcal isolates in a relatively isolated community and highlights an association between unique STs and poor outcome. |
format |
Text |
author |
Gottfreðsson, Magnús Diggle, Mathew A. Lawrie, David I. Erlendsdóttir, Helga Harðardóttir, Hjördís Kristinsson, Karl G. Clarke, Stuart C. |
author_facet |
Gottfreðsson, Magnús Diggle, Mathew A. Lawrie, David I. Erlendsdóttir, Helga Harðardóttir, Hjördís Kristinsson, Karl G. Clarke, Stuart C. |
author_sort |
Gottfreðsson, Magnús |
title |
Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
title_short |
Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
title_full |
Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
title_fullStr |
Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
title_full_unstemmed |
Neisseria meningitidis Sequence Type and Risk for Death, Iceland |
title_sort |
neisseria meningitidis sequence type and risk for death, iceland |
publisher |
Centers for Disease Control and Prevention |
publishDate |
2006 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291058 http://www.ncbi.nlm.nih.gov/pubmed/16836822 https://doi.org/10.3201/eid1207.051624 |
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Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291058 http://www.ncbi.nlm.nih.gov/pubmed/16836822 http://dx.doi.org/10.3201/eid1207.051624 |
op_doi |
https://doi.org/10.3201/eid1207.051624 |
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Emerging Infectious Diseases |
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12 |
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7 |
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1066 |
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1073 |
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1766036105400942592 |