Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds
Noggin (NOG) is an important regulator for the signaling of bone morphogenetic proteins. In this study, we sequenced the complete coding sequence of the canine NOG gene and characterized the nucleotide polymorphisms. The sequence length varied from 717 to 729 bp, depending on the number of a 6-bp ta...
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ftpubmed:oai:pubmedcentral.nih.gov:3258390 2023-05-15T15:50:09+02:00 Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds Ishii, Yuji Takizawa, Tatsuya Iwasaki, Hiroshi Fujita, Yukihiro Murakami, Masaru Groppe, Jay C. Tanaka, Kazuaki 2011-09-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258390 http://www.ncbi.nlm.nih.gov/pubmed/21882044 https://doi.org/10.1007/s10528-011-9453-5 en eng Springer US http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258390 http://www.ncbi.nlm.nih.gov/pubmed/21882044 http://dx.doi.org/10.1007/s10528-011-9453-5 © The Author(s) 2011 Article Text 2011 ftpubmed https://doi.org/10.1007/s10528-011-9453-5 2013-09-04T01:16:08Z Noggin (NOG) is an important regulator for the signaling of bone morphogenetic proteins. In this study, we sequenced the complete coding sequence of the canine NOG gene and characterized the nucleotide polymorphisms. The sequence length varied from 717 to 729 bp, depending on the number of a 6-bp tandem repeat unit (GGCGCG), an insertion that has not been observed in other mammalian NOG genes investigated to date. It results in extensions of (Gly–Ala)3–5 in the putative NOG protein. To survey the distribution of these tandem repeat polymorphisms, we analyzed 126 individuals in seven dog breeds. We identified only three alleles: (GGCGCG)3, (GGCGCG)4, and (GGCGCG)5. Although the allele frequencies were remarkably different among the breeds, the three alleles were present in all seven of the breeds and did not show any deviation from Hardy–Weinberg equilibrium. Text Canis lupus PubMed Central (PMC) Biochemical Genetics 50 1-2 12 18 |
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Article Ishii, Yuji Takizawa, Tatsuya Iwasaki, Hiroshi Fujita, Yukihiro Murakami, Masaru Groppe, Jay C. Tanaka, Kazuaki Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
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description |
Noggin (NOG) is an important regulator for the signaling of bone morphogenetic proteins. In this study, we sequenced the complete coding sequence of the canine NOG gene and characterized the nucleotide polymorphisms. The sequence length varied from 717 to 729 bp, depending on the number of a 6-bp tandem repeat unit (GGCGCG), an insertion that has not been observed in other mammalian NOG genes investigated to date. It results in extensions of (Gly–Ala)3–5 in the putative NOG protein. To survey the distribution of these tandem repeat polymorphisms, we analyzed 126 individuals in seven dog breeds. We identified only three alleles: (GGCGCG)3, (GGCGCG)4, and (GGCGCG)5. Although the allele frequencies were remarkably different among the breeds, the three alleles were present in all seven of the breeds and did not show any deviation from Hardy–Weinberg equilibrium. |
format |
Text |
author |
Ishii, Yuji Takizawa, Tatsuya Iwasaki, Hiroshi Fujita, Yukihiro Murakami, Masaru Groppe, Jay C. Tanaka, Kazuaki |
author_facet |
Ishii, Yuji Takizawa, Tatsuya Iwasaki, Hiroshi Fujita, Yukihiro Murakami, Masaru Groppe, Jay C. Tanaka, Kazuaki |
author_sort |
Ishii, Yuji |
title |
Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
title_short |
Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
title_full |
Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
title_fullStr |
Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
title_full_unstemmed |
Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds |
title_sort |
nucleotide polymorphisms in the canine noggin gene and their distribution among dog (canis lupus familiaris) breeds |
publisher |
Springer US |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258390 http://www.ncbi.nlm.nih.gov/pubmed/21882044 https://doi.org/10.1007/s10528-011-9453-5 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258390 http://www.ncbi.nlm.nih.gov/pubmed/21882044 http://dx.doi.org/10.1007/s10528-011-9453-5 |
op_rights |
© The Author(s) 2011 |
op_doi |
https://doi.org/10.1007/s10528-011-9453-5 |
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Biochemical Genetics |
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50 |
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1-2 |
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12 |
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18 |
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1766385130956390400 |