A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors....
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ftpubmed:oai:pubmedcentral.nih.gov:3234516 2023-05-15T16:10:52+02:00 A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette N Nyegaard, Mette Hedemand, Anne Als, Thomas D Wang, August G Joensen, Sofus Woldbye, David PD Koefoed, Pernille Kristensen, Ann S Kruse, Torben A Børglum, Anders D Mors, Ole 2012-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234516 http://www.ncbi.nlm.nih.gov/pubmed/21811305 https://doi.org/10.1038/ejhg.2011.148 en eng Nature Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234516 http://www.ncbi.nlm.nih.gov/pubmed/21811305 http://dx.doi.org/10.1038/ejhg.2011.148 Copyright © 2012 Macmillan Publishers Limited Article Text 2012 ftpubmed https://doi.org/10.1038/ejhg.2011.148 2013-09-03T23:44:21Z Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case–control sample. However, analyses of a larger independent Danish case–control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population. Text Faroe Islands PubMed Central (PMC) Faroe Islands European Journal of Human Genetics 20 1 84 90 |
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Article Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette N Nyegaard, Mette Hedemand, Anne Als, Thomas D Wang, August G Joensen, Sofus Woldbye, David PD Koefoed, Pernille Kristensen, Ann S Kruse, Torben A Børglum, Anders D Mors, Ole A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
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Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case–control sample. However, analyses of a larger independent Danish case–control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population. |
format |
Text |
author |
Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette N Nyegaard, Mette Hedemand, Anne Als, Thomas D Wang, August G Joensen, Sofus Woldbye, David PD Koefoed, Pernille Kristensen, Ann S Kruse, Torben A Børglum, Anders D Mors, Ole |
author_facet |
Gregersen, Noomi Dahl, Hans A Buttenschøn, Henriette N Nyegaard, Mette Hedemand, Anne Als, Thomas D Wang, August G Joensen, Sofus Woldbye, David PD Koefoed, Pernille Kristensen, Ann S Kruse, Torben A Børglum, Anders D Mors, Ole |
author_sort |
Gregersen, Noomi |
title |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_short |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_full |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_fullStr |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_full_unstemmed |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
title_sort |
genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene |
publisher |
Nature Publishing Group |
publishDate |
2012 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234516 http://www.ncbi.nlm.nih.gov/pubmed/21811305 https://doi.org/10.1038/ejhg.2011.148 |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234516 http://www.ncbi.nlm.nih.gov/pubmed/21811305 http://dx.doi.org/10.1038/ejhg.2011.148 |
op_rights |
Copyright © 2012 Macmillan Publishers Limited |
op_doi |
https://doi.org/10.1038/ejhg.2011.148 |
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European Journal of Human Genetics |
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20 |
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1 |
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84 |
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90 |
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1765995997375234048 |