Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent,...
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Molecular Diversity Preservation International
2011
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243 http://www.ncbi.nlm.nih.gov/pubmed/22163194 https://doi.org/10.3390/md9112423 |
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ftpubmed:oai:pubmedcentral.nih.gov:3229243 2023-05-15T14:05:05+02:00 Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites Abbas, Samuel Kelly, Michelle Bowling, John Sims, James Waters, Amanda Hamann, Mark 2011-11-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243 http://www.ncbi.nlm.nih.gov/pubmed/22163194 https://doi.org/10.3390/md9112423 en eng Molecular Diversity Preservation International http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243 http://www.ncbi.nlm.nih.gov/pubmed/22163194 http://dx.doi.org/10.3390/md9112423 © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Review Text 2011 ftpubmed https://doi.org/10.3390/md9112423 2013-09-03T23:24:13Z Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent, the Arctic. The Antarctic region in particular has been a more popular location for natural products discovery and has provided promising candidates for drug development. This article reviews groups of bioactive compounds that have been isolated and reported from the southern reaches of the Arctic Circle, surveys the known sponge diversity present in the Arctic waters, and details a recent sponge collection by our group in the Aleutian Islands, Alaska. The collection has yielded previously undescribed sponge species along with primary activity against opportunistic infectious diseases, malaria, and HCV. The discovery of new sponge species and bioactive crude extracts gives optimism for the isolation of new bioactive compounds from a relatively unexplored source. Text Antarc* Antarctic Arctic Alaska Aleutian Islands PubMed Central (PMC) Antarctic Arctic The Antarctic Marine Drugs 9 11 2423 2437 |
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Review Abbas, Samuel Kelly, Michelle Bowling, John Sims, James Waters, Amanda Hamann, Mark Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
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Review |
description |
Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent, the Arctic. The Antarctic region in particular has been a more popular location for natural products discovery and has provided promising candidates for drug development. This article reviews groups of bioactive compounds that have been isolated and reported from the southern reaches of the Arctic Circle, surveys the known sponge diversity present in the Arctic waters, and details a recent sponge collection by our group in the Aleutian Islands, Alaska. The collection has yielded previously undescribed sponge species along with primary activity against opportunistic infectious diseases, malaria, and HCV. The discovery of new sponge species and bioactive crude extracts gives optimism for the isolation of new bioactive compounds from a relatively unexplored source. |
format |
Text |
author |
Abbas, Samuel Kelly, Michelle Bowling, John Sims, James Waters, Amanda Hamann, Mark |
author_facet |
Abbas, Samuel Kelly, Michelle Bowling, John Sims, James Waters, Amanda Hamann, Mark |
author_sort |
Abbas, Samuel |
title |
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
title_short |
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
title_full |
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
title_fullStr |
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
title_full_unstemmed |
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites |
title_sort |
advancement into the arctic region for bioactive sponge secondary metabolites |
publisher |
Molecular Diversity Preservation International |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243 http://www.ncbi.nlm.nih.gov/pubmed/22163194 https://doi.org/10.3390/md9112423 |
geographic |
Antarctic Arctic The Antarctic |
geographic_facet |
Antarctic Arctic The Antarctic |
genre |
Antarc* Antarctic Arctic Alaska Aleutian Islands |
genre_facet |
Antarc* Antarctic Arctic Alaska Aleutian Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243 http://www.ncbi.nlm.nih.gov/pubmed/22163194 http://dx.doi.org/10.3390/md9112423 |
op_rights |
© 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md9112423 |
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Marine Drugs |
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9 |
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11 |
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2423 |
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2437 |
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1766276718766587904 |