Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, bur...
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Molecular Diversity Preservation International
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ftpubmed:oai:pubmedcentral.nih.gov:3229242 2023-05-15T15:47:16+02:00 Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current Vornanen, Matti Hassinen, Minna Haverinen, Jaakko 2011-11-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229242 http://www.ncbi.nlm.nih.gov/pubmed/22163193 https://doi.org/10.3390/md9112409 en eng Molecular Diversity Preservation International http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229242 http://www.ncbi.nlm.nih.gov/pubmed/22163193 http://dx.doi.org/10.3390/md9112409 © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2011 ftpubmed https://doi.org/10.3390/md9112409 2013-09-03T23:24:13Z Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac INa was highly TTX-sensitive with EC50-values between 1.4 and 6.6 nmol·L−1. In the snake heart, about 80% of the INa was TTX-resistant with EC50 value of 0.65 μmol·L−1, the rest being TTX-sensitive (EC50 = 0.5 nmol·L−1). Although TTX-resistance of the cardiac INa appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na+ channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates. Text Burbot PubMed Central (PMC) Marine Drugs 9 11 2409 2422 |
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Article Vornanen, Matti Hassinen, Minna Haverinen, Jaakko Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
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description |
Evolutionary origin and physiological significance of the tetrodotoxin (TTX) resistance of the vertebrate cardiac Na+ current (INa) is still unresolved. To this end, TTX sensitivity of the cardiac INa was examined in cardiac myocytes of a cyclostome (lamprey), three teleost fishes (crucian carp, burbot and rainbow trout), a clawed frog, a snake (viper) and a bird (quail). In lamprey, teleost fishes, frog and bird the cardiac INa was highly TTX-sensitive with EC50-values between 1.4 and 6.6 nmol·L−1. In the snake heart, about 80% of the INa was TTX-resistant with EC50 value of 0.65 μmol·L−1, the rest being TTX-sensitive (EC50 = 0.5 nmol·L−1). Although TTX-resistance of the cardiac INa appears to be limited to mammals and reptiles, the presence of TTX-resistant isoform of Na+ channel in the lamprey heart suggest an early evolutionary origin of the TTX-resistance, perhaps in the common ancestor of all vertebrates. |
format |
Text |
author |
Vornanen, Matti Hassinen, Minna Haverinen, Jaakko |
author_facet |
Vornanen, Matti Hassinen, Minna Haverinen, Jaakko |
author_sort |
Vornanen, Matti |
title |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_short |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_full |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_fullStr |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_full_unstemmed |
Tetrodotoxin Sensitivity of the Vertebrate Cardiac Na+ Current |
title_sort |
tetrodotoxin sensitivity of the vertebrate cardiac na+ current |
publisher |
Molecular Diversity Preservation International |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229242 http://www.ncbi.nlm.nih.gov/pubmed/22163193 https://doi.org/10.3390/md9112409 |
genre |
Burbot |
genre_facet |
Burbot |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229242 http://www.ncbi.nlm.nih.gov/pubmed/22163193 http://dx.doi.org/10.3390/md9112409 |
op_rights |
© 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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CC-BY |
op_doi |
https://doi.org/10.3390/md9112409 |
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Marine Drugs |
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9 |
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11 |
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2409 |
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2422 |
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1766382062191771648 |