Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia
The leptin gene has received intensive attention and scientific investigation for its importance in energy homeostasis and reproductive regulation in mammals. Furthermore, study of the leptin gene is of crucial importance for public health, particularly for its role in obesity, as well as for other...
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ftpubmed:oai:pubmedcentral.nih.gov:3203152 2023-05-15T18:33:33+02:00 Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia Yu, Li Jin, Wei Zhang, Xin Wang, Ding Zheng, Jin-song Yang, Guang Xu, Shi-xia Cho, Soochin Zhang, Ya-ping 2011-10-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203152 http://www.ncbi.nlm.nih.gov/pubmed/22046310 https://doi.org/10.1371/journal.pone.0026579 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203152 http://www.ncbi.nlm.nih.gov/pubmed/22046310 http://dx.doi.org/10.1371/journal.pone.0026579 Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2011 ftpubmed https://doi.org/10.1371/journal.pone.0026579 2013-09-03T21:46:20Z The leptin gene has received intensive attention and scientific investigation for its importance in energy homeostasis and reproductive regulation in mammals. Furthermore, study of the leptin gene is of crucial importance for public health, particularly for its role in obesity, as well as for other numerous physiological roles that it plays in mammals. In the present work, we report the identification of novel leptin genes in 4 species of Cetacea, and a comparison with 55 publicly available leptin sequences from mammalian genome assemblies and previous studies. Our study provides evidence for positive selection in the suborder Odontoceti (toothed whales) of the Cetacea and the family Phocidae (earless seals) of the Pinnipedia. We also detected positive selection in several leptin gene residues in these two lineages. To test whether leptin and its receptor evolved in a coordinated manner, we analyzed 24 leptin receptor gene (LPR) sequences from available mammalian genome assemblies and other published data. Unlike the case of leptin, our analyses did not find evidence of positive selection for LPR across the Cetacea and Pinnipedia lineages. In line with this, positively selected sites identified in the leptin genes of these two lineages were located outside of leptin receptor binding sites, which at least partially explains why co-evolution of leptin and its receptor was not observed in the present study. Our study provides interesting insights into current understanding of the evolution of mammalian leptin genes in response to selective pressures from life in an aquatic environment, and leads to a hypothesis that new tissue specificity or novel physiologic functions of leptin genes may have arisen in both odontocetes and phocids. Additional data from other species encompassing varying life histories and functional tests of the adaptive role of the amino acid changes identified in this study will help determine the factors that promote the adaptive evolution of the leptin genes in marine mammals. Text toothed whales PubMed Central (PMC) PLoS ONE 6 10 e26579 |
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Research Article Yu, Li Jin, Wei Zhang, Xin Wang, Ding Zheng, Jin-song Yang, Guang Xu, Shi-xia Cho, Soochin Zhang, Ya-ping Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
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The leptin gene has received intensive attention and scientific investigation for its importance in energy homeostasis and reproductive regulation in mammals. Furthermore, study of the leptin gene is of crucial importance for public health, particularly for its role in obesity, as well as for other numerous physiological roles that it plays in mammals. In the present work, we report the identification of novel leptin genes in 4 species of Cetacea, and a comparison with 55 publicly available leptin sequences from mammalian genome assemblies and previous studies. Our study provides evidence for positive selection in the suborder Odontoceti (toothed whales) of the Cetacea and the family Phocidae (earless seals) of the Pinnipedia. We also detected positive selection in several leptin gene residues in these two lineages. To test whether leptin and its receptor evolved in a coordinated manner, we analyzed 24 leptin receptor gene (LPR) sequences from available mammalian genome assemblies and other published data. Unlike the case of leptin, our analyses did not find evidence of positive selection for LPR across the Cetacea and Pinnipedia lineages. In line with this, positively selected sites identified in the leptin genes of these two lineages were located outside of leptin receptor binding sites, which at least partially explains why co-evolution of leptin and its receptor was not observed in the present study. Our study provides interesting insights into current understanding of the evolution of mammalian leptin genes in response to selective pressures from life in an aquatic environment, and leads to a hypothesis that new tissue specificity or novel physiologic functions of leptin genes may have arisen in both odontocetes and phocids. Additional data from other species encompassing varying life histories and functional tests of the adaptive role of the amino acid changes identified in this study will help determine the factors that promote the adaptive evolution of the leptin genes in marine mammals. |
format |
Text |
author |
Yu, Li Jin, Wei Zhang, Xin Wang, Ding Zheng, Jin-song Yang, Guang Xu, Shi-xia Cho, Soochin Zhang, Ya-ping |
author_facet |
Yu, Li Jin, Wei Zhang, Xin Wang, Ding Zheng, Jin-song Yang, Guang Xu, Shi-xia Cho, Soochin Zhang, Ya-ping |
author_sort |
Yu, Li |
title |
Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
title_short |
Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
title_full |
Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
title_fullStr |
Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
title_full_unstemmed |
Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia |
title_sort |
evidence for positive selection on the leptin gene in cetacea and pinnipedia |
publisher |
Public Library of Science |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203152 http://www.ncbi.nlm.nih.gov/pubmed/22046310 https://doi.org/10.1371/journal.pone.0026579 |
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toothed whales |
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toothed whales |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203152 http://www.ncbi.nlm.nih.gov/pubmed/22046310 http://dx.doi.org/10.1371/journal.pone.0026579 |
op_rights |
Yu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0026579 |
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PLoS ONE |
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e26579 |
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