In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans
The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is “No”. Using recent advances in Systems Biology in the form of large-scale metabolic reconstructions, we reassessed this question by performing a global i...
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ftpubmed:oai:pubmedcentral.nih.gov:3140964 2023-05-15T16:55:11+02:00 In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans Kaleta, Christoph de Figueiredo, Luís F. Werner, Sarah Guthke, Reinhard Ristow, Michael Schuster, Stefan 2011-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140964 http://www.ncbi.nlm.nih.gov/pubmed/21814506 https://doi.org/10.1371/journal.pcbi.1002116 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140964 http://www.ncbi.nlm.nih.gov/pubmed/21814506 http://dx.doi.org/10.1371/journal.pcbi.1002116 Kaleta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2011 ftpubmed https://doi.org/10.1371/journal.pcbi.1002116 2013-09-03T17:40:08Z The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is “No”. Using recent advances in Systems Biology in the form of large-scale metabolic reconstructions, we reassessed this question by performing a global investigation of a genome-scale human metabolic network, which had been reconstructed on the basis of experimental results. By elementary flux pattern analysis, we found numerous pathways on which gluconeogenesis from fatty acids is feasible in humans. On these pathways, four moles of acetyl-CoA are converted into one mole of glucose and two moles of CO2. Analyzing the detected pathways in detail we found that their energetic requirements potentially limit their capacity. This study has many other biochemical implications: effect of starvation, sports physiology, practically carbohydrate-free diets of inuit, as well as survival of hibernating animals and embryos of egg-laying animals. Moreover, the energetic loss associated to the usage of gluconeogenesis from fatty acids can help explain the efficiency of carbohydrate reduced and ketogenic diets such as the Atkins diet. Text inuit PubMed Central (PMC) PLoS Computational Biology 7 7 e1002116 |
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Research Article Kaleta, Christoph de Figueiredo, Luís F. Werner, Sarah Guthke, Reinhard Ristow, Michael Schuster, Stefan In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
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Research Article |
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The question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is “No”. Using recent advances in Systems Biology in the form of large-scale metabolic reconstructions, we reassessed this question by performing a global investigation of a genome-scale human metabolic network, which had been reconstructed on the basis of experimental results. By elementary flux pattern analysis, we found numerous pathways on which gluconeogenesis from fatty acids is feasible in humans. On these pathways, four moles of acetyl-CoA are converted into one mole of glucose and two moles of CO2. Analyzing the detected pathways in detail we found that their energetic requirements potentially limit their capacity. This study has many other biochemical implications: effect of starvation, sports physiology, practically carbohydrate-free diets of inuit, as well as survival of hibernating animals and embryos of egg-laying animals. Moreover, the energetic loss associated to the usage of gluconeogenesis from fatty acids can help explain the efficiency of carbohydrate reduced and ketogenic diets such as the Atkins diet. |
format |
Text |
author |
Kaleta, Christoph de Figueiredo, Luís F. Werner, Sarah Guthke, Reinhard Ristow, Michael Schuster, Stefan |
author_facet |
Kaleta, Christoph de Figueiredo, Luís F. Werner, Sarah Guthke, Reinhard Ristow, Michael Schuster, Stefan |
author_sort |
Kaleta, Christoph |
title |
In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
title_short |
In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
title_full |
In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
title_fullStr |
In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
title_full_unstemmed |
In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans |
title_sort |
in silico evidence for gluconeogenesis from fatty acids in humans |
publisher |
Public Library of Science |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140964 http://www.ncbi.nlm.nih.gov/pubmed/21814506 https://doi.org/10.1371/journal.pcbi.1002116 |
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inuit |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140964 http://www.ncbi.nlm.nih.gov/pubmed/21814506 http://dx.doi.org/10.1371/journal.pcbi.1002116 |
op_rights |
Kaleta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pcbi.1002116 |
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PLoS Computational Biology |
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7 |
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e1002116 |
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