Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well....
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ftpubmed:oai:pubmedcentral.nih.gov:3139983 2023-05-15T13:55:12+02:00 Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. 2011 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983 http://www.ncbi.nlm.nih.gov/pubmed/18996940 https://doi.org/10.1093/ecam/nen072 en eng Hindawi Publishing Corporation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983 http://www.ncbi.nlm.nih.gov/pubmed/18996940 http://dx.doi.org/10.1093/ecam/nen072 Copyright © 2011 Anna Aiello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Original Article Text 2011 ftpubmed https://doi.org/10.1093/ecam/nen072 2013-09-03T17:36:17Z Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives. Text Antarc* Antarctica Snow Petrels PubMed Central (PMC) Nivea ENVELOPE(-45.479,-45.479,-60.580,-60.580) Evidence-Based Complementary and Alternative Medicine 2011 1 8 |
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Original Article Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
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Original Article |
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Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives. |
format |
Text |
author |
Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. |
author_facet |
Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. |
author_sort |
Aiello, Anna |
title |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_short |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_full |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_fullStr |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_full_unstemmed |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_sort |
mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity) |
publisher |
Hindawi Publishing Corporation |
publishDate |
2011 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983 http://www.ncbi.nlm.nih.gov/pubmed/18996940 https://doi.org/10.1093/ecam/nen072 |
long_lat |
ENVELOPE(-45.479,-45.479,-60.580,-60.580) |
geographic |
Nivea |
geographic_facet |
Nivea |
genre |
Antarc* Antarctica Snow Petrels |
genre_facet |
Antarc* Antarctica Snow Petrels |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139983 http://www.ncbi.nlm.nih.gov/pubmed/18996940 http://dx.doi.org/10.1093/ecam/nen072 |
op_rights |
Copyright © 2011 Anna Aiello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1093/ecam/nen072 |
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Evidence-Based Complementary and Alternative Medicine |
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2011 |
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1 |
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8 |
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1766261497923633152 |