Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar)
Infectious salmon anemia (ISA) has been described as the hoof and mouth disease of salmon farming. ISA is caused by a lethal and highly communicable virus, which can have a major impact on salmon aquaculture, as demonstrated by an outbreak in Chile in 2007. A quantitative trait locus (QTL) for ISA r...
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ftpubmed:oai:pubmedcentral.nih.gov:3084937 2023-05-15T15:29:45+02:00 Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) Li, Jieying Boroevich, Keith A. Koop, Ben F. Davidson, William S. 2010-04-16 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084937 http://www.ncbi.nlm.nih.gov/pubmed/20396924 https://doi.org/10.1007/s10126-010-9284-0 en eng Springer-Verlag http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084937 http://www.ncbi.nlm.nih.gov/pubmed/20396924 http://dx.doi.org/10.1007/s10126-010-9284-0 © The Author(s) 2010 Original Article Text 2010 ftpubmed https://doi.org/10.1007/s10126-010-9284-0 2013-09-03T13:59:15Z Infectious salmon anemia (ISA) has been described as the hoof and mouth disease of salmon farming. ISA is caused by a lethal and highly communicable virus, which can have a major impact on salmon aquaculture, as demonstrated by an outbreak in Chile in 2007. A quantitative trait locus (QTL) for ISA resistance has been mapped to three microsatellite markers on linkage group (LG) 8 (Chr 15) on the Atlantic salmon genetic map. We identified bacterial artificial chromosome (BAC) clones and three fingerprint contigs from the Atlantic salmon physical map that contains these markers. We made use of the extensive BAC end sequence database to extend these contigs by chromosome walking and identified additional two markers in this region. The BAC end sequences were used to search for conserved synteny between this segment of LG8 and the fish genomes that have been sequenced. An examination of the genes in the syntenic segments of the tetraodon and medaka genomes identified candidates for association with ISA resistance in Atlantic salmon based on differential expression profiles from ISA challenges or on the putative biological functions of the proteins they encode. One gene in particular, HIV-EP2/MBP-2, caught our attention as it may influence the expression of several genes that have been implicated in the response to infection by infectious salmon anemia virus (ISAV). Therefore, we suggest that HIV-EP2/MBP-2 is a very strong candidate for the gene associated with the ISAV resistance QTL in Atlantic salmon and is worthy of further study. Text Atlantic salmon Salmo salar PubMed Central (PMC) Marine Biotechnology 13 2 232 241 |
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Original Article Li, Jieying Boroevich, Keith A. Koop, Ben F. Davidson, William S. Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
topic_facet |
Original Article |
description |
Infectious salmon anemia (ISA) has been described as the hoof and mouth disease of salmon farming. ISA is caused by a lethal and highly communicable virus, which can have a major impact on salmon aquaculture, as demonstrated by an outbreak in Chile in 2007. A quantitative trait locus (QTL) for ISA resistance has been mapped to three microsatellite markers on linkage group (LG) 8 (Chr 15) on the Atlantic salmon genetic map. We identified bacterial artificial chromosome (BAC) clones and three fingerprint contigs from the Atlantic salmon physical map that contains these markers. We made use of the extensive BAC end sequence database to extend these contigs by chromosome walking and identified additional two markers in this region. The BAC end sequences were used to search for conserved synteny between this segment of LG8 and the fish genomes that have been sequenced. An examination of the genes in the syntenic segments of the tetraodon and medaka genomes identified candidates for association with ISA resistance in Atlantic salmon based on differential expression profiles from ISA challenges or on the putative biological functions of the proteins they encode. One gene in particular, HIV-EP2/MBP-2, caught our attention as it may influence the expression of several genes that have been implicated in the response to infection by infectious salmon anemia virus (ISAV). Therefore, we suggest that HIV-EP2/MBP-2 is a very strong candidate for the gene associated with the ISAV resistance QTL in Atlantic salmon and is worthy of further study. |
format |
Text |
author |
Li, Jieying Boroevich, Keith A. Koop, Ben F. Davidson, William S. |
author_facet |
Li, Jieying Boroevich, Keith A. Koop, Ben F. Davidson, William S. |
author_sort |
Li, Jieying |
title |
Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
title_short |
Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
title_full |
Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
title_fullStr |
Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar) |
title_sort |
comparative genomics identifies candidate genes for infectious salmon anemia (isa) resistance in atlantic salmon (salmo salar) |
publisher |
Springer-Verlag |
publishDate |
2010 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084937 http://www.ncbi.nlm.nih.gov/pubmed/20396924 https://doi.org/10.1007/s10126-010-9284-0 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084937 http://www.ncbi.nlm.nih.gov/pubmed/20396924 http://dx.doi.org/10.1007/s10126-010-9284-0 |
op_rights |
© The Author(s) 2010 |
op_doi |
https://doi.org/10.1007/s10126-010-9284-0 |
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Marine Biotechnology |
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13 |
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2 |
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232 |
op_container_end_page |
241 |
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1766360186058964992 |