Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations
We previously demonstrated the activation of Caspase-6 in the hippocampus and cortex in cases of mild, moderate, severe and very severe Alzheimer disease (AD). To determine whether Caspase-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Caspase-6 and Tau cl...
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ftpubmed:oai:pubmedcentral.nih.gov:3079356 2023-05-15T15:06:47+02:00 Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations Albrecht, Steffen Bogdanovic, Nenad Ghetti, Bernardino Winblad, Bengt LeBlanc, Andréa C. 2009-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079356 http://www.ncbi.nlm.nih.gov/pubmed/19915487 https://doi.org/10.1097/NEN.0b013e3181c1da10 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079356 http://www.ncbi.nlm.nih.gov/pubmed/19915487 http://dx.doi.org/10.1097/NEN.0b013e3181c1da10 Article Text 2009 ftpubmed https://doi.org/10.1097/NEN.0b013e3181c1da10 2013-09-03T13:37:20Z We previously demonstrated the activation of Caspase-6 in the hippocampus and cortex in cases of mild, moderate, severe and very severe Alzheimer disease (AD). To determine whether Caspase-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Caspase-6 and Tau cleaved by Caspase-6 in temporal cortex and hippocampal tissue sections from cases of familial AD. The cases included 5 carrying the amyloid precursor protein K670N, M671L Swedish mutation, 1 carrying the amyloid precursor protein E693G Arctic mutation, 2 each carrying the Presenilin I M146V, F105L, A431E, V261F, Y115C mutations, and 1 with the Presenilin II N141I mutation. Active Caspase-6 immunoreactivity was found in all cases. Caspase-6 immunoreactivity was observed in neuritic plaques or cotton wool plaques in some cases, neuropil threads and neurofibrillary tangles. These results indicate that Caspase-6 is activated in familial forms of AD, as previously observed in sporadic forms. Since sporadic and familial AD cases have similar pathological features, these results support a fundamental role of Caspase-6 in the pathophysiology of both familial and sporadic AD. Text Arctic PubMed Central (PMC) Arctic Journal of Neuropathology & Experimental Neurology 68 12 1282 1293 |
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Article Albrecht, Steffen Bogdanovic, Nenad Ghetti, Bernardino Winblad, Bengt LeBlanc, Andréa C. Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
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We previously demonstrated the activation of Caspase-6 in the hippocampus and cortex in cases of mild, moderate, severe and very severe Alzheimer disease (AD). To determine whether Caspase-6 is also activated in familial AD, we performed an immunohistochemical analysis of active Caspase-6 and Tau cleaved by Caspase-6 in temporal cortex and hippocampal tissue sections from cases of familial AD. The cases included 5 carrying the amyloid precursor protein K670N, M671L Swedish mutation, 1 carrying the amyloid precursor protein E693G Arctic mutation, 2 each carrying the Presenilin I M146V, F105L, A431E, V261F, Y115C mutations, and 1 with the Presenilin II N141I mutation. Active Caspase-6 immunoreactivity was found in all cases. Caspase-6 immunoreactivity was observed in neuritic plaques or cotton wool plaques in some cases, neuropil threads and neurofibrillary tangles. These results indicate that Caspase-6 is activated in familial forms of AD, as previously observed in sporadic forms. Since sporadic and familial AD cases have similar pathological features, these results support a fundamental role of Caspase-6 in the pathophysiology of both familial and sporadic AD. |
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Text |
author |
Albrecht, Steffen Bogdanovic, Nenad Ghetti, Bernardino Winblad, Bengt LeBlanc, Andréa C. |
author_facet |
Albrecht, Steffen Bogdanovic, Nenad Ghetti, Bernardino Winblad, Bengt LeBlanc, Andréa C. |
author_sort |
Albrecht, Steffen |
title |
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
title_short |
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
title_full |
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
title_fullStr |
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
title_full_unstemmed |
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations |
title_sort |
caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein, presenilin i or presenilin ii mutations |
publishDate |
2009 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079356 http://www.ncbi.nlm.nih.gov/pubmed/19915487 https://doi.org/10.1097/NEN.0b013e3181c1da10 |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079356 http://www.ncbi.nlm.nih.gov/pubmed/19915487 http://dx.doi.org/10.1097/NEN.0b013e3181c1da10 |
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https://doi.org/10.1097/NEN.0b013e3181c1da10 |
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Journal of Neuropathology & Experimental Neurology |
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68 |
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12 |
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1282 |
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1293 |
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