Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads
Male and female hornyhead turbot (Pleuronichthys verticalis) were exposed to four concentrations (0, 0.75, 14.7 and 46.5 ng/g dry weight) of E2-amended sediment for 7 days. Sediment-derived E2 was bioavailable to the flatfish, though the route of uptake was unclear. A concentration of 46.5 ng/g E2 i...
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ftpubmed:oai:pubmedcentral.nih.gov:3040515 2023-05-15T18:41:05+02:00 Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads Rempel, Mary Ann Wang, Yinsheng Armstrong, Jeff Schlenk, Daniel 2008-02-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040515 http://www.ncbi.nlm.nih.gov/pubmed/18384871 https://doi.org/10.1016/j.marenvres.2008.02.039 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040515 http://www.ncbi.nlm.nih.gov/pubmed/18384871 http://dx.doi.org/10.1016/j.marenvres.2008.02.039 © 2008 Elsevier Ltd. All rights reserved. Article Text 2008 ftpubmed https://doi.org/10.1016/j.marenvres.2008.02.039 2013-09-03T11:10:34Z Male and female hornyhead turbot (Pleuronichthys verticalis) were exposed to four concentrations (0, 0.75, 14.7 and 46.5 ng/g dry weight) of E2-amended sediment for 7 days. Sediment-derived E2 was bioavailable to the flatfish, though the route of uptake was unclear. A concentration of 46.5 ng/g E2 in sediment led to a significant increase in vitellogenin concentrations in the plasma in both sexes after 7 days of exposure. Though plasma E2 concentrations increased significantly in males at sediment E2 concentrations of 0.75 ng/g dry weight and above, a dose-dependent increase was not observed. There was also no correlation between sediment E2 concentrations, plasma E2 concentrations, and oxidative DNA damage in male gonads. The results suggest that the DNA damage previously seen in the gonads of feral hornyhead turbot at a sewage outfall is likely not caused by acute exposure to exogenous E2 from sediments. Text Turbot PubMed Central (PMC) Marine Environmental Research 66 1 111 112 |
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Article Rempel, Mary Ann Wang, Yinsheng Armstrong, Jeff Schlenk, Daniel Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
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Male and female hornyhead turbot (Pleuronichthys verticalis) were exposed to four concentrations (0, 0.75, 14.7 and 46.5 ng/g dry weight) of E2-amended sediment for 7 days. Sediment-derived E2 was bioavailable to the flatfish, though the route of uptake was unclear. A concentration of 46.5 ng/g E2 in sediment led to a significant increase in vitellogenin concentrations in the plasma in both sexes after 7 days of exposure. Though plasma E2 concentrations increased significantly in males at sediment E2 concentrations of 0.75 ng/g dry weight and above, a dose-dependent increase was not observed. There was also no correlation between sediment E2 concentrations, plasma E2 concentrations, and oxidative DNA damage in male gonads. The results suggest that the DNA damage previously seen in the gonads of feral hornyhead turbot at a sewage outfall is likely not caused by acute exposure to exogenous E2 from sediments. |
format |
Text |
author |
Rempel, Mary Ann Wang, Yinsheng Armstrong, Jeff Schlenk, Daniel |
author_facet |
Rempel, Mary Ann Wang, Yinsheng Armstrong, Jeff Schlenk, Daniel |
author_sort |
Rempel, Mary Ann |
title |
Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
title_short |
Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
title_full |
Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
title_fullStr |
Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
title_full_unstemmed |
Uptake of estradiol from sediment by hornyhead turbot (Pleuronichthys verticalis) and effects on oxidative DNA damage in male gonads |
title_sort |
uptake of estradiol from sediment by hornyhead turbot (pleuronichthys verticalis) and effects on oxidative dna damage in male gonads |
publishDate |
2008 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040515 http://www.ncbi.nlm.nih.gov/pubmed/18384871 https://doi.org/10.1016/j.marenvres.2008.02.039 |
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Turbot |
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Turbot |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040515 http://www.ncbi.nlm.nih.gov/pubmed/18384871 http://dx.doi.org/10.1016/j.marenvres.2008.02.039 |
op_rights |
© 2008 Elsevier Ltd. All rights reserved. |
op_doi |
https://doi.org/10.1016/j.marenvres.2008.02.039 |
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Marine Environmental Research |
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66 |
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1 |
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111 |
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112 |
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1766230583941267456 |