Molecular and Evolutionary History of Melanism in North American Gray Wolves
Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus,...
Published in: | Science |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
2009
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903542 http://www.ncbi.nlm.nih.gov/pubmed/19197024 https://doi.org/10.1126/science.1165448 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:2903542 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:2903542 2023-05-15T15:50:08+02:00 Molecular and Evolutionary History of Melanism in North American Gray Wolves Anderson, Tovi M. vonHoldt, Bridgett M. Candille, Sophie I. Musiani, Marco Greco, Claudia Stahler, Daniel R. Smith, Douglas W. Padhukasahasram, Badri Randi, Ettore Leonard, Jennifer A. Bustamante, Carlos D. Ostrander, Elaine A. Tang, Hua Wayne, Robert K. Barsh, Gregory S. 2009-02-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903542 http://www.ncbi.nlm.nih.gov/pubmed/19197024 https://doi.org/10.1126/science.1165448 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903542 http://www.ncbi.nlm.nih.gov/pubmed/19197024 http://dx.doi.org/10.1126/science.1165448 Article Text 2009 ftpubmed https://doi.org/10.1126/science.1165448 2013-09-03T02:35:18Z Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus, is caused by a different melanocortin pathway component, the K locus, that encodes a beta-defensin protein that acts as an alternative ligand for Mc1r. We show that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection. The same mutation also causes melanism in the coyote, Canis latrans, and in Italian gray wolves, and hence our results demonstrate how traits selected in domesticated species can influence the morphological diversity of their wild relatives. Text Canis lupus gray wolf PubMed Central (PMC) Science 323 5919 1339 1343 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Anderson, Tovi M. vonHoldt, Bridgett M. Candille, Sophie I. Musiani, Marco Greco, Claudia Stahler, Daniel R. Smith, Douglas W. Padhukasahasram, Badri Randi, Ettore Leonard, Jennifer A. Bustamante, Carlos D. Ostrander, Elaine A. Tang, Hua Wayne, Robert K. Barsh, Gregory S. Molecular and Evolutionary History of Melanism in North American Gray Wolves |
topic_facet |
Article |
description |
Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus, is caused by a different melanocortin pathway component, the K locus, that encodes a beta-defensin protein that acts as an alternative ligand for Mc1r. We show that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection. The same mutation also causes melanism in the coyote, Canis latrans, and in Italian gray wolves, and hence our results demonstrate how traits selected in domesticated species can influence the morphological diversity of their wild relatives. |
format |
Text |
author |
Anderson, Tovi M. vonHoldt, Bridgett M. Candille, Sophie I. Musiani, Marco Greco, Claudia Stahler, Daniel R. Smith, Douglas W. Padhukasahasram, Badri Randi, Ettore Leonard, Jennifer A. Bustamante, Carlos D. Ostrander, Elaine A. Tang, Hua Wayne, Robert K. Barsh, Gregory S. |
author_facet |
Anderson, Tovi M. vonHoldt, Bridgett M. Candille, Sophie I. Musiani, Marco Greco, Claudia Stahler, Daniel R. Smith, Douglas W. Padhukasahasram, Badri Randi, Ettore Leonard, Jennifer A. Bustamante, Carlos D. Ostrander, Elaine A. Tang, Hua Wayne, Robert K. Barsh, Gregory S. |
author_sort |
Anderson, Tovi M. |
title |
Molecular and Evolutionary History of Melanism in North American Gray Wolves |
title_short |
Molecular and Evolutionary History of Melanism in North American Gray Wolves |
title_full |
Molecular and Evolutionary History of Melanism in North American Gray Wolves |
title_fullStr |
Molecular and Evolutionary History of Melanism in North American Gray Wolves |
title_full_unstemmed |
Molecular and Evolutionary History of Melanism in North American Gray Wolves |
title_sort |
molecular and evolutionary history of melanism in north american gray wolves |
publishDate |
2009 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903542 http://www.ncbi.nlm.nih.gov/pubmed/19197024 https://doi.org/10.1126/science.1165448 |
genre |
Canis lupus gray wolf |
genre_facet |
Canis lupus gray wolf |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903542 http://www.ncbi.nlm.nih.gov/pubmed/19197024 http://dx.doi.org/10.1126/science.1165448 |
op_doi |
https://doi.org/10.1126/science.1165448 |
container_title |
Science |
container_volume |
323 |
container_issue |
5919 |
container_start_page |
1339 |
op_container_end_page |
1343 |
_version_ |
1766385112700682240 |