Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy

• Published in: Epidemiology and Infection
• Main Authors: KALLIO-KOKKO, H., LAAKKONEN, J., RIZZOLI, A., TAGLIAPIETRA, V., CATTADORI, I., PERKINS, S. E., HUDSON, P. J., CRISTOFOLINI, A., VERSINI, W., VAPALAHTI, O., VAHERI, A., HENTTONEN, H.
• Format: Text
• Language: English
• Published: Cambridge University Press 2006
• Subjects: Research Article; Microtus arvalis
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870443; http://www.ncbi.nlm.nih.gov/pubmed/16371172; https://doi.org/10.1017/S0950268805005431

The spatial and temporal distribution of hantavirus and arenavirus antibody-positive wild rodents in Trentino, Italy, was studied using immunofluorescence assays (IFA) in two long-term sites trapped in 2000–2003, and six other sites trapped in 2002. The overall hantavirus seroprevalence in the bank voles, Clethrionomys glareolus (n=229) screened for Puumala virus (PUUV) antibodies was 0·4%, and that for Apodemus flavicollis mice (n=1416) screened for Dobrava virus (DOBV) antibodies was 0·2%. Antibodies against lymphocytic choriomeningitis virus (LCMV) were found in 82 (5·6%) of the 1472 tested rodents; the seroprevalence being 6·1% in A. flavicollis (n=1181), 3·3% in C. glareolus (n=276), and 14·3% in Microtus arvalis (n=7). Of the serum samples of 488 forestry workers studied by IFA, 12 were LCMV-IgG positive (2·5%) and one DOBV-IgG positive (0·2%), however, the latter could not be confirmed DOBV-specific with a neutralization assay. Our results show a widespread distribution but low prevalence of DOBV in Trentino, and demonstrate that the arenavirus antibodies are a common finding in several other rodent species besides the house mouse.