An ignored risk factor in toxicology: The total imprecision of exposure assessment
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were...
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ftpubmed:oai:pubmedcentral.nih.gov:2856963 2023-05-15T16:10:49+02:00 An ignored risk factor in toxicology: The total imprecision of exposure assessment Grandjean, Philippe Budtz-Jørgensen, Esben 2010-01-25 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963 http://www.ncbi.nlm.nih.gov/pubmed/20419070 https://doi.org/10.1351/PAC-CON-09-05-04 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963 http://www.ncbi.nlm.nih.gov/pubmed/20419070 http://dx.doi.org/10.1351/PAC-CON-09-05-04 Article Text 2010 ftpubmed https://doi.org/10.1351/PAC-CON-09-05-04 2013-09-02T23:38:29Z Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. Text Faroe Islands PubMed Central (PMC) Faroe Islands Pure and Applied Chemistry 82 2 383 391 |
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Article Grandjean, Philippe Budtz-Jørgensen, Esben An ignored risk factor in toxicology: The total imprecision of exposure assessment |
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Article |
description |
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. |
format |
Text |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_sort |
Grandjean, Philippe |
title |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_short |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_fullStr |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full_unstemmed |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_sort |
ignored risk factor in toxicology: the total imprecision of exposure assessment |
publishDate |
2010 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963 http://www.ncbi.nlm.nih.gov/pubmed/20419070 https://doi.org/10.1351/PAC-CON-09-05-04 |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
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Faroe Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963 http://www.ncbi.nlm.nih.gov/pubmed/20419070 http://dx.doi.org/10.1351/PAC-CON-09-05-04 |
op_doi |
https://doi.org/10.1351/PAC-CON-09-05-04 |
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Pure and Applied Chemistry |
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82 |
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2 |
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383 |
op_container_end_page |
391 |
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1765995963108818944 |