Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice
Oyster extracts have been reported to have many bioactive peptides. But the function of oyster peptides produced by proteolysis is still unknown. In this study, the oligopeptide-enriched hydrolysates from oyster (Crassostrea gigas) were produced using the protease from Bacillus sp. SM98011 at labora...
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Molecular Diversity Preservation International
2010
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852837 http://www.ncbi.nlm.nih.gov/pubmed/20390104 https://doi.org/10.3390/md8020255 |
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ftpubmed:oai:pubmedcentral.nih.gov:2852837 2023-05-15T15:58:02+02:00 Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice Wang, Yu-Kai He, Hai-Lun Wang, Guo-Fan Wu, Hao Zhou, Bai-Cheng Chen, Xiu-Lan Zhang, Yu-Zhong 2010-02-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852837 http://www.ncbi.nlm.nih.gov/pubmed/20390104 https://doi.org/10.3390/md8020255 en eng Molecular Diversity Preservation International http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852837 http://www.ncbi.nlm.nih.gov/pubmed/20390104 http://dx.doi.org/10.3390/md8020255 © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). CC-BY Article Text 2010 ftpubmed https://doi.org/10.3390/md8020255 2013-09-02T23:23:11Z Oyster extracts have been reported to have many bioactive peptides. But the function of oyster peptides produced by proteolysis is still unknown. In this study, the oligopeptide-enriched hydrolysates from oyster (Crassostrea gigas) were produced using the protease from Bacillus sp. SM98011 at laboratory level, and scaled up to pilot (100 L) and plant (1,000 L) levels with the same conditions. And the antitumor activity and immunostimulating effects of the oyster hydrolysates in BALB/c mice were investigated. The growth of transplantable sarcoma-S180 was obviously inhibited in a dose-dependent manner in BALB/c mice given the oyster hydrolysates. Mice receiving 0.25, 0.5 and 1 mg/g of body weight by oral gavage had 6.8%, 30.6% and 48% less tumor growth, respectively. Concurrently, the weight coefficients of the thymus and the spleen, the activity of natural killer (NK) cells, the spleen proliferation of lymphocytes and the phagocytic rate of macrophages in S180-bearing mice significantly increased after administration of the oyster hydrolysates. These results demonstrated that oyster hydrolysates produced strong immunostimulating effects in mice, which might result in its antitumor activity. The antitumor and immunostimulating effects of oyster hydrolysates prepared in this study reveal its potential for tumor therapy and as a dietary supplement with immunostimulatory activity. Text Crassostrea gigas PubMed Central (PMC) Marine Drugs 8 2 255 268 |
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Article Wang, Yu-Kai He, Hai-Lun Wang, Guo-Fan Wu, Hao Zhou, Bai-Cheng Chen, Xiu-Lan Zhang, Yu-Zhong Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
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Article |
description |
Oyster extracts have been reported to have many bioactive peptides. But the function of oyster peptides produced by proteolysis is still unknown. In this study, the oligopeptide-enriched hydrolysates from oyster (Crassostrea gigas) were produced using the protease from Bacillus sp. SM98011 at laboratory level, and scaled up to pilot (100 L) and plant (1,000 L) levels with the same conditions. And the antitumor activity and immunostimulating effects of the oyster hydrolysates in BALB/c mice were investigated. The growth of transplantable sarcoma-S180 was obviously inhibited in a dose-dependent manner in BALB/c mice given the oyster hydrolysates. Mice receiving 0.25, 0.5 and 1 mg/g of body weight by oral gavage had 6.8%, 30.6% and 48% less tumor growth, respectively. Concurrently, the weight coefficients of the thymus and the spleen, the activity of natural killer (NK) cells, the spleen proliferation of lymphocytes and the phagocytic rate of macrophages in S180-bearing mice significantly increased after administration of the oyster hydrolysates. These results demonstrated that oyster hydrolysates produced strong immunostimulating effects in mice, which might result in its antitumor activity. The antitumor and immunostimulating effects of oyster hydrolysates prepared in this study reveal its potential for tumor therapy and as a dietary supplement with immunostimulatory activity. |
format |
Text |
author |
Wang, Yu-Kai He, Hai-Lun Wang, Guo-Fan Wu, Hao Zhou, Bai-Cheng Chen, Xiu-Lan Zhang, Yu-Zhong |
author_facet |
Wang, Yu-Kai He, Hai-Lun Wang, Guo-Fan Wu, Hao Zhou, Bai-Cheng Chen, Xiu-Lan Zhang, Yu-Zhong |
author_sort |
Wang, Yu-Kai |
title |
Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
title_short |
Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
title_full |
Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
title_fullStr |
Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
title_full_unstemmed |
Oyster (Crassostrea gigas) Hydrolysates Produced on a Plant Scale Have Antitumor Activity and Immunostimulating Effects in BALB/c Mice |
title_sort |
oyster (crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in balb/c mice |
publisher |
Molecular Diversity Preservation International |
publishDate |
2010 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852837 http://www.ncbi.nlm.nih.gov/pubmed/20390104 https://doi.org/10.3390/md8020255 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852837 http://www.ncbi.nlm.nih.gov/pubmed/20390104 http://dx.doi.org/10.3390/md8020255 |
op_rights |
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/md8020255 |
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Marine Drugs |
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8 |
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2 |
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255 |
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268 |
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1766393751309123584 |