Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element
Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we compared nucleotide sequences and activities of mammalian Hoxc8 early enhancers. The nucleotide sequence...
Main Authors: | , , , , |
---|---|
Format: | Text |
Language: | English |
Published: |
The National Academy of Sciences
1998
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28062 http://www.ncbi.nlm.nih.gov/pubmed/9860988 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:28062 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:28062 2023-05-15T15:36:52+02:00 Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element Shashikant, Cooduvalli S. Kim, Chang B. Borbély, Marc A. Wang, Wayne C. H. Ruddle, Frank H. 1998-12-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28062 http://www.ncbi.nlm.nih.gov/pubmed/9860988 en eng The National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28062 http://www.ncbi.nlm.nih.gov/pubmed/9860988 Copyright © 1998, The National Academy of Sciences Biological Sciences Text 1998 ftpubmed 2013-08-29T07:23:38Z Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we compared nucleotide sequences and activities of mammalian Hoxc8 early enhancers. The nucleotide sequence of the early enhancer region is extremely conserved among mammalian clades, with five previously described cis-acting elements, A–E, being invariant. However, a 4-bp deletion within element C of the Hoxc8 early enhancer sequence is observed in baleen whales. When assayed in transgenic mouse embryos, a baleen whale enhancer (unlike other mammalian enhancers) directs expression of the reporter gene to more posterior regions of the neural tube but fails to direct expression to posterior mesoderm. We suggest that regulation of Hoxc8 in baleen whales differs from other mammalian species and may be associated with variation in axial morphology. Text baleen whale baleen whales PubMed Central (PMC) |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Biological Sciences |
spellingShingle |
Biological Sciences Shashikant, Cooduvalli S. Kim, Chang B. Borbély, Marc A. Wang, Wayne C. H. Ruddle, Frank H. Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
topic_facet |
Biological Sciences |
description |
Variations in regulatory regions of developmental control genes have been implicated in the divergence of axial morphologies. To find potentially significant changes in cis-regulatory regions, we compared nucleotide sequences and activities of mammalian Hoxc8 early enhancers. The nucleotide sequence of the early enhancer region is extremely conserved among mammalian clades, with five previously described cis-acting elements, A–E, being invariant. However, a 4-bp deletion within element C of the Hoxc8 early enhancer sequence is observed in baleen whales. When assayed in transgenic mouse embryos, a baleen whale enhancer (unlike other mammalian enhancers) directs expression of the reporter gene to more posterior regions of the neural tube but fails to direct expression to posterior mesoderm. We suggest that regulation of Hoxc8 in baleen whales differs from other mammalian species and may be associated with variation in axial morphology. |
format |
Text |
author |
Shashikant, Cooduvalli S. Kim, Chang B. Borbély, Marc A. Wang, Wayne C. H. Ruddle, Frank H. |
author_facet |
Shashikant, Cooduvalli S. Kim, Chang B. Borbély, Marc A. Wang, Wayne C. H. Ruddle, Frank H. |
author_sort |
Shashikant, Cooduvalli S. |
title |
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
title_short |
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
title_full |
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
title_fullStr |
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
title_full_unstemmed |
Comparative studies on mammalian Hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
title_sort |
comparative studies on mammalian hoxc8 early enhancer sequence reveal a baleen whale-specific deletion of a cis-acting element |
publisher |
The National Academy of Sciences |
publishDate |
1998 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28062 http://www.ncbi.nlm.nih.gov/pubmed/9860988 |
genre |
baleen whale baleen whales |
genre_facet |
baleen whale baleen whales |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC28062 http://www.ncbi.nlm.nih.gov/pubmed/9860988 |
op_rights |
Copyright © 1998, The National Academy of Sciences |
_version_ |
1766367308669779968 |