Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations

• Published in: Human Mutation
• Main Authors: Jorge-Nebert, Lucia F., Jiang, Zhengwen, Chakraborty, Ranajit, Watson, Joanna, Jin, Li, McGarvey, Stephen T., Deka, Ranjan, Nebert, Daniel W.
• Format: Text
• Language: English
• Published: 2010
• Subjects: Article; Pehuenche; Dogrib
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837; http://www.ncbi.nlm.nih.gov/pubmed/19802894; https://doi.org/10.1002/humu.21132

The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene m...