Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations
The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene m...
Published in: | Human Mutation |
---|---|
Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
2010
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837 http://www.ncbi.nlm.nih.gov/pubmed/19802894 https://doi.org/10.1002/humu.21132 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:2797837 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:2797837 2023-05-15T16:02:14+02:00 Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations Jorge-Nebert, Lucia F. Jiang, Zhengwen Chakraborty, Ranajit Watson, Joanna Jin, Li McGarvey, Stephen T. Deka, Ranjan Nebert, Daniel W. 2010-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837 http://www.ncbi.nlm.nih.gov/pubmed/19802894 https://doi.org/10.1002/humu.21132 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837 http://www.ncbi.nlm.nih.gov/pubmed/19802894 http://dx.doi.org/10.1002/humu.21132 Article Text 2010 ftpubmed https://doi.org/10.1002/humu.21132 2013-09-02T20:05:02Z The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene might have evolved more rapidly due to environmental (dietary) pressures. A population genetics study might confirm this premise. We combined 60 CYP1A1_CYP1A2 SNPs found in the present study (eight New Guinea Highlanders, eight Samoans, four Dogrib, four Teribe, four Pehuenche, one Caucasian) with those found in a previous study (six West Africans, four Han Chinese, six Germans, four Samoans, and four Dogrib)—yielding a total of 106 SNPs in 106 chromosomes. Resequencing of Oceanians plus Amerindians in the present study yielded 21 New World SNPs (~20%), of which 17 are not previously reported in any SNP database. Various tests revealed selective pressures for both genes and both haploblocks; unfortunately, differences in rates of evolution between the two genes were undetectable. Fay & Wu's H test revealed a “hitchhiking event” centered around four SNPs in the CYP1A1 3'-UTR; a study in silico identified different microRNA-binding patterns in the hitchhiked region, when the mutations were present compared with the mutations absent. Text Dogrib PubMed Central (PMC) Pehuenche ENVELOPE(-60.783,-60.783,-62.450,-62.450) Human Mutation 31 1 27 40 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Jorge-Nebert, Lucia F. Jiang, Zhengwen Chakraborty, Ranajit Watson, Joanna Jin, Li McGarvey, Stephen T. Deka, Ranjan Nebert, Daniel W. Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
topic_facet |
Article |
description |
The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene might have evolved more rapidly due to environmental (dietary) pressures. A population genetics study might confirm this premise. We combined 60 CYP1A1_CYP1A2 SNPs found in the present study (eight New Guinea Highlanders, eight Samoans, four Dogrib, four Teribe, four Pehuenche, one Caucasian) with those found in a previous study (six West Africans, four Han Chinese, six Germans, four Samoans, and four Dogrib)—yielding a total of 106 SNPs in 106 chromosomes. Resequencing of Oceanians plus Amerindians in the present study yielded 21 New World SNPs (~20%), of which 17 are not previously reported in any SNP database. Various tests revealed selective pressures for both genes and both haploblocks; unfortunately, differences in rates of evolution between the two genes were undetectable. Fay & Wu's H test revealed a “hitchhiking event” centered around four SNPs in the CYP1A1 3'-UTR; a study in silico identified different microRNA-binding patterns in the hitchhiked region, when the mutations were present compared with the mutations absent. |
format |
Text |
author |
Jorge-Nebert, Lucia F. Jiang, Zhengwen Chakraborty, Ranajit Watson, Joanna Jin, Li McGarvey, Stephen T. Deka, Ranjan Nebert, Daniel W. |
author_facet |
Jorge-Nebert, Lucia F. Jiang, Zhengwen Chakraborty, Ranajit Watson, Joanna Jin, Li McGarvey, Stephen T. Deka, Ranjan Nebert, Daniel W. |
author_sort |
Jorge-Nebert, Lucia F. |
title |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_short |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_full |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_fullStr |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_full_unstemmed |
Analysis of Human CYP1A1 and CYP1A2 Genes and Their Shared Bidirectional Promoter in Eight World Populations |
title_sort |
analysis of human cyp1a1 and cyp1a2 genes and their shared bidirectional promoter in eight world populations |
publishDate |
2010 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837 http://www.ncbi.nlm.nih.gov/pubmed/19802894 https://doi.org/10.1002/humu.21132 |
long_lat |
ENVELOPE(-60.783,-60.783,-62.450,-62.450) |
geographic |
Pehuenche |
geographic_facet |
Pehuenche |
genre |
Dogrib |
genre_facet |
Dogrib |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797837 http://www.ncbi.nlm.nih.gov/pubmed/19802894 http://dx.doi.org/10.1002/humu.21132 |
op_doi |
https://doi.org/10.1002/humu.21132 |
container_title |
Human Mutation |
container_volume |
31 |
container_issue |
1 |
container_start_page |
27 |
op_container_end_page |
40 |
_version_ |
1766397817218138112 |