Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer’s disease

• Published in: European Journal of Neuroscience
• Main Authors: Rival, Thomas, Page, Richard M, Chandraratna, Dhianjali S, Sendall, Timothy J, Ryder, Edward, Liu, Beinan, Lewis, Huw, Rosahl, Thomas, Hider, Robert, Camargo, L M, Shearman, Mark S, Crowther, Damian C, Lomas, David A
• Format: Text
• Language: English
• Published: Blackwell Publishing Ltd 2009
• Subjects: Molecular and Developmental Neuroscience; Arctic; Fenton
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777252; http://www.ncbi.nlm.nih.gov/pubmed/19519625; https://doi.org/10.1111/j.1460-9568.2009.06701.x

The mechanism by which aggregates of the β-amyloid peptide (Aβ) mediate their toxicity is uncertain. We show here that the expression of the 42-amino-acid isoform of Aβ (Aβ1–42) changes the expression of genes involved in oxidative stress in a Drosophila model of Alzheimer’s disease. A subsequent ge...